Cardiac beat-to-beat alternations driven by unusual spiral waves

Yun Kim Tae, Sung J. Woo, Seong M. Hwang, Hee Hong Jin, Kyoung Jin Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Alternans, a beat-to-beat temporal alternation in the sequence of heartbeats, is a known precursor of the development of cardiac fibrillation, leading to sudden cardiac death. The equally important precursor of cardiac arrhythmias is the rotating spiral wave of electro-mechanical activity, or reentry, on the heart tissue. Here, we show that these two seemingly different phenomena can have a remarkable relationship. In well controlled in vitro tissue cultures, isotropic populations of rat ventricular myocytes sustaining a temporal rhythm of alternans can support period-2 oscillatory reentries and vice versa. These reentries bear "line defects" across which the phase of local excitation slips rather abruptly by 2π, when a full period-2 cycle of alternans completes in 4π. In other words, the cells belonging to the line defects are period-1 oscillatory, whereas all of the others in the bulk medium are period-2 oscillatory. We also find that a slowly rotating line defect results in a quasi-periodic like oscillation in the bulk medium. Some key features of these phenomena can be well reproduced in computer simulations of a nonlinear reaction-diffusion model.

Original languageEnglish
Pages (from-to)11639-11642
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number28
DOIs
Publication statusPublished - 2007 Jul 10

Fingerprint

Sudden Cardiac Death
Computer Simulation
Muscle Cells
Cardiac Arrhythmias
Population
In Vitro Techniques

Keywords

  • Cardiac reentry
  • Discordant alternans
  • Line defect
  • Nodal lines
  • Period-2 oscillation

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Cardiac beat-to-beat alternations driven by unusual spiral waves. / Tae, Yun Kim; Woo, Sung J.; Hwang, Seong M.; Jin, Hee Hong; Lee, Kyoung Jin.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 28, 10.07.2007, p. 11639-11642.

Research output: Contribution to journalArticle

Tae, Yun Kim ; Woo, Sung J. ; Hwang, Seong M. ; Jin, Hee Hong ; Lee, Kyoung Jin. / Cardiac beat-to-beat alternations driven by unusual spiral waves. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 28. pp. 11639-11642.
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