Cardiovascular responses to cocaine placebo in humans: A preliminary report

Nicola Cascella, Carles Muntaner, Karen M. Kumor, Craig T. Nagoshi, Jerome H. Jaffe, Michael A. Sherer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cardiovascular responses after placebo-cocaine injections were in the same direction as the effect of cocaine iv in 22 male volunteers. Subjects received iv placebo in a room where they had been given repeated doses of iv cocaine. The placebo response consisted of an increase from baseline values of systolic and diastolic blood pressure and pulse rate. The control group, 8 subjects, which was not exposed to a conditioning phase, showed a smaller increase in the pulse rate and systolic blood pressure after the placebo injection. The results, in accordance with animal literature, suggest the existence of cocaine-conditioned effects in humans.

Original languageEnglish
Pages (from-to)285-295
Number of pages11
JournalBiological Psychiatry
Volume25
Issue number3
DOIs
Publication statusPublished - 1989 Feb 1

ASJC Scopus subject areas

  • Biological Psychiatry

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  • Cite this

    Cascella, N., Muntaner, C., Kumor, K. M., Nagoshi, C. T., Jaffe, J. H., & Sherer, M. A. (1989). Cardiovascular responses to cocaine placebo in humans: A preliminary report. Biological Psychiatry, 25(3), 285-295. https://doi.org/10.1016/0006-3223(89)90176-5