Cardiovascular risk factors cause cortical thinning in cognitively impaired patients: Relationships among cardiovascular risk factors, white matter hyperintensities, and cortical atrophy

Sang Won Seo, Jong Min Lee, Kiho Im, Jun Sung Park, Sook Hui Kim, Sung Tae Kim, Joong Hyun Ahn, Min Jeong Kim, Geon Ha Kim, Jong Hun Kim, Jee Hoon Roh, Hae Kwan Cheong, Duk L. Na

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Cardiovascular risk factors are associated with cognitive impairments. However, the effects of cardiovascular risk factors on the topography of cortical thinning have not yet been studied in patients with mild cognitive impairment (MCI) or dementia. Thus, we aimed to evaluate the topography of cortical thinning related to cardiovascular risk factors and the relationships among cardiovascular risk factors, white matter hyperintensities (WMH), and cortical atrophy. Participants included 226 patients with Alzheimer disease or subcortical vascular dementia and 135 patients with amnestic MCI or subcortical vascular MCI. We automatically measured the volume of WMH and cortical thickness. Hypertension was associated with cortical thinning in the frontal and perisylvian regions, and cortical thinning related to diabetes mellitus (DM) occurred in the frontal region. In path analyses, hypertension accounted for 0.04 of the frontal thinning with the mediation of WMH and 0.16 without the mediation of WMH. In case of DM, it accounted for 0.02 of the frontal thinning with the mediation of WMH and 0.13 without the mediation of WMH. Hypertension and DM predominantly affected frontal thinning both with and without the mediation of WMH, where the effects without the mediation of WMH were greater than those with the mediation of WMH.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalAlzheimer Disease and Associated Disorders
Volume26
Issue number2
DOIs
Publication statusPublished - 2012 Apr
Externally publishedYes

Keywords

  • cortical thickness
  • diabetes mellitus
  • hyperlipidemia
  • hypertension
  • white matter hyperintensities

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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