Cartilage tissue engineering using a elastic poly (L-lactide-co-ε- caprolactone) scaffold

Youngmee Jung, Soo Hyun Kim, Sang Heon Kim, Young Ha Kim, Byoung Goo Min

Research output: Contribution to journalArticle

Abstract

Mechano-active scaffolds were fabricated from very elastic poly(L-lactide-co-ε-carprolactone). The scaffolds with 80% porosity and 300-500 um pore size were prepared by a gel-pressing method. As a control group for elastic properties of polymer scaffolds, rigid poly L-lactide scaffolds were fabricated. The scaffolds were seeded with chondrocytes and cultured to evaluate the effect of elastic properties of polymer scaffolds for the differentiation and the ECM secretion of chondrocytes. Also, the chondrocytes-seeded constructs were implanted in nude mice subcutaneously to investigate their biocompatibility and cartilage formation. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation of dynamic environment in the dynamic body systems. Histological analysis showed that implants of PLCL constructs formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae. Consequently, the elastic PLCL scaffolds could be used to engineer cartilage in mechanically dynamic environments.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16
Externally publishedYes

Keywords

  • Cartilage tissue engineering
  • Chondrocytes
  • Elastic poly-(I-lactide-co-ε- caprolactone) scaffold

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

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  • Cite this

    Jung, Y., Kim, S. H., Kim, S. H., Kim, Y. H., & Min, B. G. (2007). Cartilage tissue engineering using a elastic poly (L-lactide-co-ε- caprolactone) scaffold. Key Engineering Materials, 342-343, 405-408.