Case characteristics, hyperacute treatment, and outcome information from the clinical research center for stroke-fifth division registry in South Korea

Beom Joon Kim, Jong Moo Park, Kyusik Kang, Soo Joo Lee, Youngchai Ko, Jae Guk Kim, Jae Kwan Cha, Dae Hyun Kim, Hyun Wook Nah, Moon Ku Han, Tai Hwan Park, Sang Soon Park, Kyung Bok Lee, Jun Lee, Keun Sik Hong, Yong Jin Cho, Byung Chul Lee, Kyung Ho Yu, Mi Sun Oh, Dong Eog KimWi Sun Ryu, Ki Hyun Cho, Joon Tae Kim, Jay Chol Choi, Wook Joo Kim, Dong Ick Shin, Min Ju Yeo, Sung Il Sohn, Jeong Ho Hong, Juneyoung Lee, Ji Sung Lee, Byung Woo Yoon, Hee Joon Bae

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

Characteristics of stroke cases, acute stroke care, and outcomes after stroke differ according to geographical and cultural background. To provide epidemiological and clinical data on stroke care in South Korea, we analyzed a prospective multicenter clinical stroke registry, the Clinical Research Center for Stroke-Fifth Division (CRCS-5). Patients were 58% male with a mean age of 67.2±12.9 years and median National Institutes of Health Stroke Scale score of 3 [1-8] points. Over the 6 years of operation, temporal trends were documented including increasing utilization of recanalization treatment with shorter onset-to-arrival delay and decremental length of stay. Acute recanalization treatment was performed in 12.7% of cases with endovascular treatment utilized in 36%, but the proportion of endovascular recanalization varied across centers. Door-to-IV alteplase delay had a median of 45 [33-68] min. The rate of symptomatic hemorrhagic transformation (HT) was 7%, and that of any HT was 27% among recanalization-treated cases. Early neurological deterioration occurred in 15% of cases and were associated with longer length of stay and poorer 3-month outcomes. The proportion of mRS scores of 0-1 was 42% on discharge, 50% at 3 months, and 55% at 1 year after the index stroke. Recurrent stroke up to 1 year occurred in 4.5% of patients; the rate was higher among older individuals and those with neurologically severe deficits. The above findings will be compared with other Asian and US registry data in this article.

Original languageEnglish
Pages (from-to)38-53
Number of pages16
JournalJournal of Stroke
Volume17
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Republic of Korea
Registries
Stroke
Research
Length of Stay
National Institutes of Health (U.S.)
Tissue Plasminogen Activator
Therapeutics

Keywords

  • Case profile
  • Hyperacute treatment
  • Outcome
  • Recurrent event
  • South Korea
  • Stroke registry
  • Thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Case characteristics, hyperacute treatment, and outcome information from the clinical research center for stroke-fifth division registry in South Korea. / Kim, Beom Joon; Park, Jong Moo; Kang, Kyusik; Lee, Soo Joo; Ko, Youngchai; Kim, Jae Guk; Cha, Jae Kwan; Kim, Dae Hyun; Nah, Hyun Wook; Han, Moon Ku; Park, Tai Hwan; Park, Sang Soon; Lee, Kyung Bok; Lee, Jun; Hong, Keun Sik; Cho, Yong Jin; Lee, Byung Chul; Yu, Kyung Ho; Oh, Mi Sun; Kim, Dong Eog; Ryu, Wi Sun; Cho, Ki Hyun; Kim, Joon Tae; Choi, Jay Chol; Kim, Wook Joo; Shin, Dong Ick; Yeo, Min Ju; Sohn, Sung Il; Hong, Jeong Ho; Lee, Juneyoung; Lee, Ji Sung; Yoon, Byung Woo; Bae, Hee Joon.

In: Journal of Stroke, Vol. 17, No. 1, 01.01.2015, p. 38-53.

Research output: Contribution to journalReview article

Kim, BJ, Park, JM, Kang, K, Lee, SJ, Ko, Y, Kim, JG, Cha, JK, Kim, DH, Nah, HW, Han, MK, Park, TH, Park, SS, Lee, KB, Lee, J, Hong, KS, Cho, YJ, Lee, BC, Yu, KH, Oh, MS, Kim, DE, Ryu, WS, Cho, KH, Kim, JT, Choi, JC, Kim, WJ, Shin, DI, Yeo, MJ, Sohn, SI, Hong, JH, Lee, J, Lee, JS, Yoon, BW & Bae, HJ 2015, 'Case characteristics, hyperacute treatment, and outcome information from the clinical research center for stroke-fifth division registry in South Korea', Journal of Stroke, vol. 17, no. 1, pp. 38-53. https://doi.org/10.5853/jos.2015.17.1.38
Kim, Beom Joon ; Park, Jong Moo ; Kang, Kyusik ; Lee, Soo Joo ; Ko, Youngchai ; Kim, Jae Guk ; Cha, Jae Kwan ; Kim, Dae Hyun ; Nah, Hyun Wook ; Han, Moon Ku ; Park, Tai Hwan ; Park, Sang Soon ; Lee, Kyung Bok ; Lee, Jun ; Hong, Keun Sik ; Cho, Yong Jin ; Lee, Byung Chul ; Yu, Kyung Ho ; Oh, Mi Sun ; Kim, Dong Eog ; Ryu, Wi Sun ; Cho, Ki Hyun ; Kim, Joon Tae ; Choi, Jay Chol ; Kim, Wook Joo ; Shin, Dong Ick ; Yeo, Min Ju ; Sohn, Sung Il ; Hong, Jeong Ho ; Lee, Juneyoung ; Lee, Ji Sung ; Yoon, Byung Woo ; Bae, Hee Joon. / Case characteristics, hyperacute treatment, and outcome information from the clinical research center for stroke-fifth division registry in South Korea. In: Journal of Stroke. 2015 ; Vol. 17, No. 1. pp. 38-53.
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AU - Ko, Youngchai

AU - Kim, Jae Guk

AU - Cha, Jae Kwan

AU - Kim, Dae Hyun

AU - Nah, Hyun Wook

AU - Han, Moon Ku

AU - Park, Tai Hwan

AU - Park, Sang Soon

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AU - Kim, Joon Tae

AU - Choi, Jay Chol

AU - Kim, Wook Joo

AU - Shin, Dong Ick

AU - Yeo, Min Ju

AU - Sohn, Sung Il

AU - Hong, Jeong Ho

AU - Lee, Juneyoung

AU - Lee, Ji Sung

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AU - Bae, Hee Joon

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N2 - Characteristics of stroke cases, acute stroke care, and outcomes after stroke differ according to geographical and cultural background. To provide epidemiological and clinical data on stroke care in South Korea, we analyzed a prospective multicenter clinical stroke registry, the Clinical Research Center for Stroke-Fifth Division (CRCS-5). Patients were 58% male with a mean age of 67.2±12.9 years and median National Institutes of Health Stroke Scale score of 3 [1-8] points. Over the 6 years of operation, temporal trends were documented including increasing utilization of recanalization treatment with shorter onset-to-arrival delay and decremental length of stay. Acute recanalization treatment was performed in 12.7% of cases with endovascular treatment utilized in 36%, but the proportion of endovascular recanalization varied across centers. Door-to-IV alteplase delay had a median of 45 [33-68] min. The rate of symptomatic hemorrhagic transformation (HT) was 7%, and that of any HT was 27% among recanalization-treated cases. Early neurological deterioration occurred in 15% of cases and were associated with longer length of stay and poorer 3-month outcomes. The proportion of mRS scores of 0-1 was 42% on discharge, 50% at 3 months, and 55% at 1 year after the index stroke. Recurrent stroke up to 1 year occurred in 4.5% of patients; the rate was higher among older individuals and those with neurologically severe deficits. The above findings will be compared with other Asian and US registry data in this article.

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KW - Stroke registry

KW - Thrombolysis

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