TY - JOUR
T1 - Case-control association study for 10 genes in patients with schizophrenia
T2 - Influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics
AU - Crisafulli, Concetta
AU - Chiesa, Alberto
AU - Han, Changsu
AU - Lee, Soo Jung
AU - Park, Moon Ho
AU - Balzarro, Beatrice
AU - Andrisano, Costanza
AU - Patkar, Ashwin A.
AU - Pae, Chi Un
AU - Serretti, Alessandro
N1 - Funding Information:
Acknowledgments This work was supported by the Institute of Clinical Medicine Research of Bucheon St. Mary’s Hospital, Research Fund, 2011.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/4
Y1 - 2012/4
N2 - The aim of this study is to investigate possible associations between a set of single-nucleotide polymorphisms (SNPs) within 10 genes with Schizophrenia (SCZ) and response to antipsychotics in Korean in-patients treated with antipsychotics. Two hundred and twenty-one SCZ in-patients and 170 psychiatrically healthy controls were genotyped for 42 SNPs within ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. Rs10042486 within 5HTR1A was associated with both SCZ and clinical improvement on PANSS total scores as well as on PANSS positive and PANSS negative scores. The haplotype analyses focusing on the four, three and two blocks' haplotypes within 5HTR1A confirmed such findings as well. We did not observe any significant association between the remaining genetic variants under investigation in this study and clinical outcomes. Our preliminary findings suggest that rs10042486 within 5HTR1A promoter region could be associated with SCZ and with clinical improvement on PANSS total, positive and negative scores in Korean patients with SCZ. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.
AB - The aim of this study is to investigate possible associations between a set of single-nucleotide polymorphisms (SNPs) within 10 genes with Schizophrenia (SCZ) and response to antipsychotics in Korean in-patients treated with antipsychotics. Two hundred and twenty-one SCZ in-patients and 170 psychiatrically healthy controls were genotyped for 42 SNPs within ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. Rs10042486 within 5HTR1A was associated with both SCZ and clinical improvement on PANSS total scores as well as on PANSS positive and PANSS negative scores. The haplotype analyses focusing on the four, three and two blocks' haplotypes within 5HTR1A confirmed such findings as well. We did not observe any significant association between the remaining genetic variants under investigation in this study and clinical outcomes. Our preliminary findings suggest that rs10042486 within 5HTR1A promoter region could be associated with SCZ and with clinical improvement on PANSS total, positive and negative scores in Korean patients with SCZ. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.
KW - 5HTR1A and GPRIN2
KW - ABCB1
KW - ABCB4
KW - Antipsychotics
KW - CLOCK
KW - CPLX1
KW - CPLX2
KW - NRG1
KW - SYN2
KW - Schizophrenia
KW - TAP2
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U2 - 10.1007/s00406-011-0278-3
DO - 10.1007/s00406-011-0278-3
M3 - Article
C2 - 22120873
AN - SCOPUS:84862838701
VL - 262
SP - 199
EP - 205
JO - Archiv fur Psychiatrie und Nervenkrankheiten
JF - Archiv fur Psychiatrie und Nervenkrankheiten
SN - 0003-9373
IS - 3
ER -
