Case-control association study for 10 genes in patients with schizophrenia: Influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics

Concetta Crisafulli, Alberto Chiesa, Changsu Han, Soo Jung Lee, Moon Ho Park, Beatrice Balzarro, Costanza Andrisano, Ashwin A. Patkar, Chi Un Pae, Alessandro Serretti

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    The aim of this study is to investigate possible associations between a set of single-nucleotide polymorphisms (SNPs) within 10 genes with Schizophrenia (SCZ) and response to antipsychotics in Korean in-patients treated with antipsychotics. Two hundred and twenty-one SCZ in-patients and 170 psychiatrically healthy controls were genotyped for 42 SNPs within ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. Rs10042486 within 5HTR1A was associated with both SCZ and clinical improvement on PANSS total scores as well as on PANSS positive and PANSS negative scores. The haplotype analyses focusing on the four, three and two blocks' haplotypes within 5HTR1A confirmed such findings as well. We did not observe any significant association between the remaining genetic variants under investigation in this study and clinical outcomes. Our preliminary findings suggest that rs10042486 within 5HTR1A promoter region could be associated with SCZ and with clinical improvement on PANSS total, positive and negative scores in Korean patients with SCZ. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

    Original languageEnglish
    Pages (from-to)199-205
    Number of pages7
    JournalEuropean Archives of Psychiatry and Clinical Neuroscience
    Volume262
    Issue number3
    DOIs
    Publication statusPublished - 2012 Apr

    Keywords

    • 5HTR1A and GPRIN2
    • ABCB1
    • ABCB4
    • Antipsychotics
    • CLOCK
    • CPLX1
    • CPLX2
    • NRG1
    • SYN2
    • Schizophrenia
    • TAP2

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry
    • Pharmacology (medical)

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