Case of disseminated vesicles of herpes zoster developing one day before the onset of local eruption in a hospitalized immunocompromised patient

Tomotaka Mabuchi, Hanako Yamaoka, Masayuki Kato, Norihiro Ikoma, Shiho Tamiya, Hae Jun Song, Naoya Nakamura, Akira Ozawa

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Disseminated herpes zoster is not rare in immunocompromised patient. It is defined as at least 20 lesions in multiple dermatomes that occur within a week of the onset of local eruption. Herein, we report that a case of disseminated vesicles of herpes zoster (HZ) that developed one day before the onset of local eruption in an immunocompromised patient. A 44 year-old Japanese male, who had been in the hospital with acute myelocytic leukemia, developed disseminated hemorrhagic vesicles of 5 to 10 mm in diameter. The next day, grouped vesicles, including hemorrhagic vesicles erupted on the right side of the second to third cervical (C2-C3) dermatomes. At this point, the diagnosis was made as disseminated herpes zoster. The activation of varicella-zoster virus (VZV) is believed to be due to waning of VZV-specific memory T cell responses. In our case, the memory immunity to VZV which had been increased by last episode of HZ might affect on the appearance of skin eruptions.

Original languageEnglish
Pages (from-to)52-54
Number of pages3
JournalTokai Journal of Experimental and Clinical Medicine
Issue number2
Publication statusPublished - 2013 Jul 1



  • Disseminated herpes zoster
  • Generalized herpes zoster
  • Recurrence
  • Reinfection
  • VZV-specific memory T cells

ASJC Scopus subject areas

  • Medicine(all)

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