Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

Lijun An, Jun Ma, Xueyuan Yang, Yue Liang, Huimei Wang, Muhetaer Tuerhong, Namrita Lall, Munira Abudukeremu, Yi Zhang, Dongho Lee, Jing Xu, Xiaohui Wu, Yuanqiang Guo

Research output: Contribution to journalArticle

Abstract

Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

Original languageEnglish
Article number103758
JournalBioorganic Chemistry
Volume98
DOIs
Publication statusPublished - 2020 May

Keywords

  • Anti-inflammation
  • Casearia kurzii
  • Homotriterpenoid
  • Molecular docking
  • Zebrafish model

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    An, L., Ma, J., Yang, X., Liang, Y., Wang, H., Tuerhong, M., Lall, N., Abudukeremu, M., Zhang, Y., Lee, D., Xu, J., Wu, X., & Guo, Y. (2020). Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo. Bioorganic Chemistry, 98, [103758]. https://doi.org/10.1016/j.bioorg.2020.103758