Abstract
A copper-catalyzed enantioselective Claisen rearrangement of easily accessible enolphosphonates using the commercially available PhBOX as the chiral ligand was developed. A wide range of rearrangement products with contiguous tertiary and all-carbon quaternary centers were obtained in excellent yields and stereoselectivities. The α-ketophosphonate substituent in the products could be easily transformed into other functional groups.
Original language | English |
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Pages (from-to) | 8264-8267 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2012 Aug 13 |
Keywords
- BOX ligands
- Claisen rearrangement
- asymmetric catalysis
- copper
- quaternary carbon centers
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)