Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients

Hwa Young Lee, Yong Ku Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrelated manic patients who met strict DSM-IV criteria for bipolar I disorder and 157 healthy unrelated controls. All subjects were of Korean ethnicity. To evaluate the clinical symptoms, we used the Young Mania Rating Scale at baseline and 6 weeks after treatment. No statistically significant difference in genotype distribution was found between manic patients and normal controls. There was also no significant difference in symptomatology among the genotypes in manic patients. In therapeutic response, however, patients with the Met/Met genotype were significantly more frequent in the non-responder than in the responder group. Our results suggest that the COMT gene polymorphism in the therapeutic response to mood stabilizers in manic patients. Further studies with a larger number of subjects and well-controlled design will be required to better understand the role of the COMT gene polymorphism on the therapeutic response to mood stabilizer in manic patients.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalPsychiatry Research
Volume175
Issue number1-2
DOIs
Publication statusPublished - 2010 Jan 30

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Catechol O-Methyltransferase
Bipolar Disorder
Genotype
Genes
Therapeutics
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry

Keywords

  • Catechol-O-methyltransferase (COMT)
  • Manic patients
  • Polymorphism
  • Therapeutic response

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients. / Lee, Hwa Young; Kim, Yong Ku.

In: Psychiatry Research, Vol. 175, No. 1-2, 30.01.2010, p. 63-66.

Research output: Contribution to journalArticle

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