Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis

Ju Hee Ryu, Sun Ah Kim, Heebeom Koo, Ji Young Yhee, Aeju Lee, Jin Hee Na, Inchan Youn, Kuiwon Choi, Ick Chan Kwon, Byung Soo Kim, Kwang Meyung Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields.

Original languageEnglish
Pages (from-to)17631-17634
Number of pages4
JournalJournal of Materials Chemistry
Volume21
Issue number44
DOIs
Publication statusPublished - 2011 Nov 28
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemistry(all)

Cite this

Ryu, J. H., Kim, S. A., Koo, H., Yhee, J. Y., Lee, A., Na, J. H., Youn, I., Choi, K., Kwon, I. C., Kim, B. S., & Kim, K. M. (2011). Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis. Journal of Materials Chemistry, 21(44), 17631-17634. https://doi.org/10.1039/c1jm13064a