Kausalzusammenhang zwischen rheumatoider Arthritis und vermindertem Risiko für M. Alzheimer: Eine Mendel-Randomisierungsstudie

Translated title of the contribution: Causal association between rheumatoid arthritis and a decreased risk of Alzheimer’s disease: A Mendelian randomization study

S. C. Bae, Y. H. Lee

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Objective: This study aimed to examine whether rheumatoid arthritis (RA) is causally associated with Alzheimer’s disease (AD). Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics datasets from three-stage trans-ethnic genome-wide association studies (GWAS) meta-analyses of 29,880 RA cases and 73,758 controls as exposures and a meta-analysis of 4 GWAS datasets consisting of 17,008 AD cases and 37,154 controls of European descent as outcomes. Results: We selected 80 single nucleotide polymorphisms (SNPs) from GWAS data on RA as instrumental variables (IVs), 60 of which were associated with RA on a genome-wide significance level. The IVW method showed evidence to support an inverse causal association between RA and AD (β = −0.039, standard error [SE] = 0.017, P = 0.021). MR-Egger regression revealed that directional pleiotropy was unlikely to be a source of bias in the results (intercept = 0.002; P = 0.649). The MR-Egger analysis showed no causal association between RA and AD (β = −0.050, SE = 0.030, P = 0.096). However, the weighted median approach showed that RA and AD were causally linked (β = −0.078, SE = 0.024, P = 0.001). The funnel plot did not show heterogeneity between IV estimates based on the individual variants. Conclusions: The MR analysis supports that RA was causally associated with a reduced risk of AD.

    Translated title of the contributionCausal association between rheumatoid arthritis and a decreased risk of Alzheimer’s disease: A Mendelian randomization study
    Original languageGerman
    Pages (from-to)359-364
    Number of pages6
    JournalZeitschrift fur Rheumatologie
    Volume78
    Issue number4
    DOIs
    Publication statusPublished - 2019 May 1

    Keywords

    • Alzheimer’s disease
    • Causal association
    • Mendelian randomization
    • Rheumatoid arthritis
    • Susceptibility

    ASJC Scopus subject areas

    • Rheumatology

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