Causal relationship between years of education and the occurrence of rheumatoid arthritis

Sang Cheol Bae, Young Ho Lee

Research output: Contribution to journalArticle

Abstract

Objective To search out whether or not years of education is causally related to rheumatoid arthritis (RA). Method We conducted a two-sample Mendelian randomisation (MR) analysis employing inverse-variance weighted (IVW), weighted median and MR-Egger regression analysis. We chose statistic data of years of education from the UK Biobank genome-wide association studies (GWASs) (n=293 723) as the exposure and a meta-analysis of GWASs of RA with autoantibody (n=5539) and European controls (n=20 169) as the outcome. Results We selected a total of 49 single nucleotide polymorphisms as instrumental variables (IVs). The IVW method instructed an inverse causative relationship between years of education and RA (β=- 0.039, SE=0.283, p=0.008). MR-Egger regression test showed that directional pleiotropy seems not to bias the MR results (intercept=0.028; p=0.358). MR-Egger analysis demonstrated no causative relationship between RA and years of education (β=- 2.320, SE=1.709, p=0.181). However, the weighted median approach indicated a causative association between RA and years of education (β=-0.950, SE=0.355, p=0.008). Conclusions The MR analysis supported a potential inverse causative relationship between years of education and development of RA.

Original languageEnglish
Pages (from-to)378-381
Number of pages4
JournalPostgraduate Medical Journal
Volume95
Issue number1125
DOIs
Publication statusPublished - 2019 Jul 1

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Mendelian Randomization Analysis
Rheumatoid Arthritis
Education
Random Allocation
Genome-Wide Association Study
Autoantibodies
Single Nucleotide Polymorphism
Meta-Analysis
Regression Analysis

Keywords

  • educational attainment
  • mendelian randomization
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Causal relationship between years of education and the occurrence of rheumatoid arthritis. / Bae, Sang Cheol; Lee, Young Ho.

In: Postgraduate Medical Journal, Vol. 95, No. 1125, 01.07.2019, p. 378-381.

Research output: Contribution to journalArticle

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