CD1-restricted T-cell responses and microbial infection

Se-Ho Park, Albert Bendelac

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

Original languageEnglish
Pages (from-to)788-792
Number of pages5
JournalNature
Volume406
Issue number6797
DOIs
Publication statusPublished - 2000 Aug 17
Externally publishedYes

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Histocompatibility
T-Lymphocytes
Lipids
Peptides
Antigen Presentation
Infection
Mammals
Glycoproteins
Vaccines

ASJC Scopus subject areas

  • General

Cite this

CD1-restricted T-cell responses and microbial infection. / Park, Se-Ho; Bendelac, Albert.

In: Nature, Vol. 406, No. 6797, 17.08.2000, p. 788-792.

Research output: Contribution to journalArticle

Park, Se-Ho ; Bendelac, Albert. / CD1-restricted T-cell responses and microbial infection. In: Nature. 2000 ; Vol. 406, No. 6797. pp. 788-792.
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