CD1-restricted T-cell responses and microbial infection

Se Ho Park, Albert Bendelac

Research output: Contribution to journalReview article

101 Citations (Scopus)

Abstract

CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

Original languageEnglish
Pages (from-to)788-792
Number of pages5
JournalNature
Volume406
Issue number6797
DOIs
Publication statusPublished - 2000 Aug 17
Externally publishedYes

ASJC Scopus subject areas

  • General

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