CD14 receptor gene promoter polymorphism: Awakening maternal immunity during pregnancy

J. E. Lim, T. Kim, N. W. Lee, M. J. Oh, H. J. Seol, J. Y. Min, Hai J. Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated whether monocyte CD14 receptor gene promoter polymorphisms were associated with the development and severity of pre-eclampsia. We genotyped the CD14-260 C/T polymorphism in 36 pre-eclamptic patients and 52 healthy pregnant controls. A total of 30.6% and 69.4% of pre-eclamptic patients had the C and T alleles, respectively, and 48.0% and 52.0% of the controls, respectively. More pre-eclamptic patients were TT homozygotes compared with controls (50.0% versus 13.5%). In pre-eclamptic patients, the TT homozygotes exhibited a significantly higher mean systolic blood pressure compared with the non-TT homozygotes (173 ± 28 mmHg versus 153 ± 22 mmHg). We also noted a tendency towards increased proteinuria and placental abruption in the TT homozygotes compared with the non-TT homozygotes. We conclude that CD14 gene promoter polymorphisms appear to be a risk factor for pre-eclampsia. With further research, these findings might form the basis of a prognostic tool for pre-eclampsia.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalJournal of International Medical Research
Volume34
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • CD14 receptor
  • Immune system
  • Monocyte
  • Polymorphism
  • Pre-eclampsia
  • Pregnant women

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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