CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury

Hirokuni Akahori, Vinit Karmali, Rohini Polavarapu, Alicia N. Lyle, Daiana Weiss, Eric Shin, Ahsan Husain, Nawazish Naqvi, Richard Van Dam, Anwer Habib, Cheol Ung Choi, Adrienne L. King, Kimberly Pachura, W. Robert Taylor, David J. Lefer, Aloke V. Finn

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Macrophages are an essential component of the immune response to ischaemic injury and play an important role in promoting inflammation and its resolution, which is necessary for tissue repair. The type I transmembrane glycoprotein CD163 is exclusively expressed on macrophages, where it acts as a receptor for haemoglobin:haptoglobin complexes. An extracellular portion of CD163 circulates in the blood as a soluble protein, for which no physiological function has so far been described. Here we show that during ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, a secreted pro-inflammatory cytokine of the tumour necrosis factor family, to regulate TWEAK-induced activation of canonical nuclear factor-? B (NF-? B) and Notch signalling necessary for myogenic progenitor cell proliferation. Mice with deletion of CD163 have transiently elevated levels of TWEAK, which stimulate muscle satellite cell proliferation and tissue regeneration in their ischaemic and non-ischaemic limbs. These results reveal a role for soluble CD163 in regulating muscle regeneration after ischaemic injury.

Original languageEnglish
Article number7792
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 2015 Aug 5

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury'. Together they form a unique fingerprint.

  • Cite this

    Akahori, H., Karmali, V., Polavarapu, R., Lyle, A. N., Weiss, D., Shin, E., Husain, A., Naqvi, N., Van Dam, R., Habib, A., Choi, C. U., King, A. L., Pachura, K., Taylor, W. R., Lefer, D. J., & Finn, A. V. (2015). CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury. Nature Communications, 6, [7792]. https://doi.org/10.1038/ncomms8792