CD1a on Langerhans cells controls inflammatory skin disease

Ji Hyung Kim, Yu Hu, Tang Yongqing, Jessica Kim, Victoria A. Hughes, Jérôme Le Nours, Elsa A. Marquez, Anthony W. Purcell, Qi Wan, Masahiko Sugita, Jamie Rossjohn, Florian Winau

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

CD1a is a lipid-presenting molecule that is abundantly expressed on Langerhans cells. However, the in vivo role of CD1a has remained unclear, principally because CD1a is lacking in mice. Through the use of mice with transgenic expression of CD1a, we found that the plant-derived lipid urushiol triggered CD1a-dependent skin inflammation driven by CD4 + helper T cells that produced the cytokines IL-17 and IL-22 (T H 17 cells). Human subjects with poison-ivy dermatitis had a similar cytokine signature following CD1a-mediated recognition of urushiol. Among various urushiol congeners, we identified diunsaturated pentadecylcatechol (C15:2) as the dominant antigen for CD1a-restricted T cells. We determined the crystal structure of the CD1a-urushiol (C15:2) complex, demonstrating the molecular basis of urushiol interaction with the antigen-binding cleft of CD1a. In a mouse model and in patients with psoriasis, CD1a amplified inflammatory responses that were mediated by T H 17 cells that reacted to self lipid antigens. Treatment with blocking antibodies to CD1a alleviated skin inflammation. Thus, we propose CD1a as a potential therapeutic target in inflammatory skin diseases.

Original languageEnglish
Pages (from-to)1159-1166
Number of pages8
JournalNature Immunology
Volume17
Issue number10
DOIs
Publication statusPublished - 2016 Sep 20
Externally publishedYes

Fingerprint

Langerhans Cells
Skin Diseases
Lipids
Toxicodendron Dermatitis
Cytokines
Inflammation
Skin
Blocking Antibodies
Interleukin-17
Autoantigens
Helper-Inducer T-Lymphocytes
Psoriasis
Transgenic Mice
urushiol
T-Lymphocytes
Antigens
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Kim, J. H., Hu, Y., Yongqing, T., Kim, J., Hughes, V. A., Le Nours, J., ... Winau, F. (2016). CD1a on Langerhans cells controls inflammatory skin disease. Nature Immunology, 17(10), 1159-1166. https://doi.org/10.1038/ni.3523

CD1a on Langerhans cells controls inflammatory skin disease. / Kim, Ji Hyung; Hu, Yu; Yongqing, Tang; Kim, Jessica; Hughes, Victoria A.; Le Nours, Jérôme; Marquez, Elsa A.; Purcell, Anthony W.; Wan, Qi; Sugita, Masahiko; Rossjohn, Jamie; Winau, Florian.

In: Nature Immunology, Vol. 17, No. 10, 20.09.2016, p. 1159-1166.

Research output: Contribution to journalArticle

Kim, JH, Hu, Y, Yongqing, T, Kim, J, Hughes, VA, Le Nours, J, Marquez, EA, Purcell, AW, Wan, Q, Sugita, M, Rossjohn, J & Winau, F 2016, 'CD1a on Langerhans cells controls inflammatory skin disease', Nature Immunology, vol. 17, no. 10, pp. 1159-1166. https://doi.org/10.1038/ni.3523
Kim JH, Hu Y, Yongqing T, Kim J, Hughes VA, Le Nours J et al. CD1a on Langerhans cells controls inflammatory skin disease. Nature Immunology. 2016 Sep 20;17(10):1159-1166. https://doi.org/10.1038/ni.3523
Kim, Ji Hyung ; Hu, Yu ; Yongqing, Tang ; Kim, Jessica ; Hughes, Victoria A. ; Le Nours, Jérôme ; Marquez, Elsa A. ; Purcell, Anthony W. ; Wan, Qi ; Sugita, Masahiko ; Rossjohn, Jamie ; Winau, Florian. / CD1a on Langerhans cells controls inflammatory skin disease. In: Nature Immunology. 2016 ; Vol. 17, No. 10. pp. 1159-1166.
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