CD36 is required for myoblast fusion during myogenic differentiation

Seung Yoon Park, Youngeun Yun, In San Kim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Recently, CD36 has been found to be involved in the cytokine-induced fusion of macrophage. Myoblast fusion to form multinucleated myotubes is required for myogenesis and muscle regeneration. Because a search of gene expression database revealed the attenuation of CD36 expression in the muscles of muscular dystrophy patients, the possibility that CD36 could be required for myoblast fusion was investigated. CD36 expression was markedly up-regulated during myoblast differentiation and localized in multinucleated myotubes. Knockdown of endogenous CD36 significantly decreased the expression of myogenic markers as well as myotube formation. These results support the notion that CD36 plays an important role in cell fusion during myogenic differentiation. Our finding will aid the elucidation of the common mechanism governing cell-to-cell fusion in various fusion models.

Original languageEnglish
Pages (from-to)705-710
Number of pages6
JournalBiochemical and biophysical research communications
Volume427
Issue number4
DOIs
Publication statusPublished - 2012 Nov 2
Externally publishedYes

Keywords

  • CD36
  • Cell fusion
  • Myoblast fusion
  • Myogenic differentiation
  • Skeletal muscle

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'CD36 is required for myoblast fusion during myogenic differentiation'. Together they form a unique fingerprint.

Cite this