Cell culture-based influenza vaccines as alternatives to egg-based vaccines

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Influenza viruses have raised public health concerns by seasonal epidemics and intermittent pandemics. Vaccination is considered as the most effective method for preventing influenza infection in humans. Current influenza vaccines are mostly produced in fertile chicken eggs. However, disadvantages of egg-based vaccines, such as egg dependency, labor-intensive manufacturing system, and huddle for large-scale output, allow us to make an alternative method. A cell-culture platform may be a fine alternative for the next generation vaccine technique. Compared with a classical egg-based method, cell-grown vaccines provide stable pipeline even in the pandemic situation with shorter lead-in times. In addition, cell-grown vaccines are flexible for altering production scales because stocked cell batches can be easily sub-cultured in large quantity without worrying avian diseases and a resultant decrease in egg production. By World Health Organization, MDCK, PER.C6, and Vero cells are only recommended for manufacturing influenza vaccines. In this review, we discuss the necessity, immunogenicity, and efficacy of cell-grown influenza vaccines compared with egg-based vaccines.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalJournal of Bacteriology and Virology
Volume43
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1
Externally publishedYes

Fingerprint

Influenza Vaccines
Ovum
Vaccines
Cell Culture Techniques
Pandemics
Bird Diseases
Vero Cells
Orthomyxoviridae
Human Influenza
Eggs
Chickens
Vaccination
Public Health
Infection

Keywords

  • Egg
  • Influenza
  • MDCK
  • Vaccine
  • Vero

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

Cite this

Cell culture-based influenza vaccines as alternatives to egg-based vaccines. / Lee, Ilseob; Kim, Jin Il; Park, Man-Seong.

In: Journal of Bacteriology and Virology, Vol. 43, No. 1, 01.01.2013, p. 9-17.

Research output: Contribution to journalReview article

@article{11813462bbf44271be1652f561e439a1,
title = "Cell culture-based influenza vaccines as alternatives to egg-based vaccines",
abstract = "Influenza viruses have raised public health concerns by seasonal epidemics and intermittent pandemics. Vaccination is considered as the most effective method for preventing influenza infection in humans. Current influenza vaccines are mostly produced in fertile chicken eggs. However, disadvantages of egg-based vaccines, such as egg dependency, labor-intensive manufacturing system, and huddle for large-scale output, allow us to make an alternative method. A cell-culture platform may be a fine alternative for the next generation vaccine technique. Compared with a classical egg-based method, cell-grown vaccines provide stable pipeline even in the pandemic situation with shorter lead-in times. In addition, cell-grown vaccines are flexible for altering production scales because stocked cell batches can be easily sub-cultured in large quantity without worrying avian diseases and a resultant decrease in egg production. By World Health Organization, MDCK, PER.C6, and Vero cells are only recommended for manufacturing influenza vaccines. In this review, we discuss the necessity, immunogenicity, and efficacy of cell-grown influenza vaccines compared with egg-based vaccines.",
keywords = "Egg, Influenza, MDCK, Vaccine, Vero",
author = "Ilseob Lee and Kim, {Jin Il} and Man-Seong Park",
year = "2013",
month = "1",
day = "1",
doi = "10.4167/jbv.2013.43.1.9",
language = "English",
volume = "43",
pages = "9--17",
journal = "Journal of Bacteriology and Virology",
issn = "1598-2467",
publisher = "Chonnam National University Medical School",
number = "1",

}

TY - JOUR

T1 - Cell culture-based influenza vaccines as alternatives to egg-based vaccines

AU - Lee, Ilseob

AU - Kim, Jin Il

AU - Park, Man-Seong

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Influenza viruses have raised public health concerns by seasonal epidemics and intermittent pandemics. Vaccination is considered as the most effective method for preventing influenza infection in humans. Current influenza vaccines are mostly produced in fertile chicken eggs. However, disadvantages of egg-based vaccines, such as egg dependency, labor-intensive manufacturing system, and huddle for large-scale output, allow us to make an alternative method. A cell-culture platform may be a fine alternative for the next generation vaccine technique. Compared with a classical egg-based method, cell-grown vaccines provide stable pipeline even in the pandemic situation with shorter lead-in times. In addition, cell-grown vaccines are flexible for altering production scales because stocked cell batches can be easily sub-cultured in large quantity without worrying avian diseases and a resultant decrease in egg production. By World Health Organization, MDCK, PER.C6, and Vero cells are only recommended for manufacturing influenza vaccines. In this review, we discuss the necessity, immunogenicity, and efficacy of cell-grown influenza vaccines compared with egg-based vaccines.

AB - Influenza viruses have raised public health concerns by seasonal epidemics and intermittent pandemics. Vaccination is considered as the most effective method for preventing influenza infection in humans. Current influenza vaccines are mostly produced in fertile chicken eggs. However, disadvantages of egg-based vaccines, such as egg dependency, labor-intensive manufacturing system, and huddle for large-scale output, allow us to make an alternative method. A cell-culture platform may be a fine alternative for the next generation vaccine technique. Compared with a classical egg-based method, cell-grown vaccines provide stable pipeline even in the pandemic situation with shorter lead-in times. In addition, cell-grown vaccines are flexible for altering production scales because stocked cell batches can be easily sub-cultured in large quantity without worrying avian diseases and a resultant decrease in egg production. By World Health Organization, MDCK, PER.C6, and Vero cells are only recommended for manufacturing influenza vaccines. In this review, we discuss the necessity, immunogenicity, and efficacy of cell-grown influenza vaccines compared with egg-based vaccines.

KW - Egg

KW - Influenza

KW - MDCK

KW - Vaccine

KW - Vero

UR - http://www.scopus.com/inward/record.url?scp=84922687007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922687007&partnerID=8YFLogxK

U2 - 10.4167/jbv.2013.43.1.9

DO - 10.4167/jbv.2013.43.1.9

M3 - Review article

VL - 43

SP - 9

EP - 17

JO - Journal of Bacteriology and Virology

JF - Journal of Bacteriology and Virology

SN - 1598-2467

IS - 1

ER -