Cell Cycle Dysregulation Induced by Cytoplasm of Lactococcus lactis ssp. lactis in SNUC2A, a Colon Cancer Cell Line

Ji Yeon Kim, Hee Jong Woo, Young S. Kim, Kyoung Heon Kim, Hyong Joo Lee

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The anticancer effect of cytoplasmic fraction from Lactococcus lactis ssp. lactis, which had showed strong antiproliferative activity against SNUC2A human colon cancer cell line in the previous study, was investigated. The proliferation of SNUC2A was inhibited by the treatment with cytoplasmic fraction of Lactococcus lactis ssp. lactis in a dose-dependent and partially reversible manner. After exposure to the cytoplasmic fraction of Lc. lactis for 72 h, strong antiproliferative activity was efficiently induced through S-phase accumulation in SNUC2A cells. Analysis of cell cycle regulatory proteins demonstrated that the cytoplasmic fraction enhanced the levels of p21 CIP1 and cyclin A, decreased cyclin E protein, and slightly reduced the activity of cyclin-dependent kinase 2 (CDK2).

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalNutrition and Cancer
Volume46
Issue number2
Publication statusPublished - 2003 Dec 16

Fingerprint

Lactococcus lactis
cyclins
colorectal neoplasms
Colonic Neoplasms
cell cycle
Cell Cycle
Cytoplasm
cytoplasm
cell lines
Cyclin-Dependent Kinase 2
Cyclin A
Cell Line
Cyclin E
Cell Cycle Proteins
cyclin-dependent kinase
regulatory proteins
S Phase
interphase
dosage
Proteins

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Oncology

Cite this

Cell Cycle Dysregulation Induced by Cytoplasm of Lactococcus lactis ssp. lactis in SNUC2A, a Colon Cancer Cell Line. / Kim, Ji Yeon; Woo, Hee Jong; Kim, Young S.; Kim, Kyoung Heon; Lee, Hyong Joo.

In: Nutrition and Cancer, Vol. 46, No. 2, 16.12.2003, p. 197-201.

Research output: Contribution to journalArticle

Kim, Ji Yeon ; Woo, Hee Jong ; Kim, Young S. ; Kim, Kyoung Heon ; Lee, Hyong Joo. / Cell Cycle Dysregulation Induced by Cytoplasm of Lactococcus lactis ssp. lactis in SNUC2A, a Colon Cancer Cell Line. In: Nutrition and Cancer. 2003 ; Vol. 46, No. 2. pp. 197-201.
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