Cell 'Trap and release' using novel microfluidic 'hydraulic jump' trap

D. Mitra, Y. Park, Yeonho Choi, H. Patel, B. Pham, J. R. Waldeisen, T. Kang, L. P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cell 'trap and release' in microfluidic devices is critical for on-chip concentration purposes and dynamic microarrays. However, most existing mechanical trapping modalities lack release capabilities and some employ very complex or abrasive trapping mechanisms. Here we describe a novel cell 'trap and release' device, which employs principles similar to the 'hydraulic jump' phenomenon in nature. This new microfluidic 'hydraulic jump' trap is gentle on cells, allows hydrodynamic control over 'trap and release,' and enables rapid mass transfer of nutrients and analytes. Hence, it provides a new platform to analyze and manipulate living cells in physiological microenvironments.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1595-1597
Number of pages3
Volume3
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

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Keywords

  • Cell 'trap and release'
  • Hydraulic jump
  • Microfluidics
  • On-chip sample preparation

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Mitra, D., Park, Y., Choi, Y., Patel, H., Pham, B., Waldeisen, J. R., Kang, T., & Lee, L. P. (2010). Cell 'Trap and release' using novel microfluidic 'hydraulic jump' trap. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 3, pp. 1595-1597)