Cell 'trap and release' in microfluidic devices is critical for on-chip concentration purposes and dynamic microarrays. However, most existing mechanical trapping modalities lack release capabilities and some employ very complex or abrasive trapping mechanisms. Here we describe a novel cell 'trap and release' device, which employs principles similar to the 'hydraulic jump' phenomenon in nature. This new microfluidic 'hydraulic jump' trap is gentle on cells, allows hydrodynamic control over 'trap and release,' and enables rapid mass transfer of nutrients and analytes. Hence, it provides a new platform to analyze and manipulate living cells in physiological microenvironments.
|Title of host publication||14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010|
|Number of pages||3|
|Publication status||Published - 2010 Dec 1|
|Event||14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands|
Duration: 2010 Oct 3 → 2010 Oct 7
|Other||14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010|
|Period||10/10/3 → 10/10/7|
- Cell 'trap and release'
- Hydraulic jump
- On-chip sample preparation
ASJC Scopus subject areas
- Control and Systems Engineering