Cellular and ras changes in the hearts of young obese rats

Kee Soo Ha, Kee Hwan Yoo, Hyung-Eun Yim, Giyoung Jang, In Sun Bae, Young Sook Hong, Joo Won Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Obesity during childhood increases the risk of cardiac disease, hypertension, and other complications in adulthood. We investigated the cellular and renin-angiotensin system changes of the heart in obese young rats. We used Sprague-Dawley rats and early obesity was induced by overfeeding through adjusting the number of male pups per dam during the first 28 days of life. The body weight, heart weight, blood pressure, serum glucose, and blood pressure were assessed and we performed echocardiography, proliferating cell nuclear antigen (PCNA); assessment, apoptosis and Masson's trichrome staining, and Western blotting and the results were compared between the normal litter (NL, control) and the small litter (SL, obesity). There were no differences in blood pressure and serum glucose, but the body weight increased 61.2% and the interventricular septal thickness in diastole on the echocardiography was increased in the SL. There was hyperplasia of the PCNA cells and apoptotic cells without cellular hypertrophy or change of the amount of collagen in the SL. On Western blotting, rennin, and angiotensin II type 2 receptor (AT2R) were increased without a change of angiotensin II type 1 receptor (AT1R) in the SL. Early obesity caused echocardiographically detected septal hypertrophy and an increase of cellular turnover. Renin and AT2R were upregulated without a change of AT1R and the increase of AT2R was regarded as a cardioprotective effect against the pathologic conditions caused by the early obesity.

Original languageEnglish
Pages (from-to)659-666
Number of pages8
JournalPediatric Cardiology
Volume32
Issue number5
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

Angiotensin Type 2 Receptor
Obesity
Angiotensin Type 1 Receptor
Proliferating Cell Nuclear Antigen
Blood Pressure
Hypertrophy
Echocardiography
Western Blotting
Body Weight
Chymosin
Glucose
Diastole
Pediatric Obesity
Renin-Angiotensin System
Serum
Renin
Hyperplasia
Sprague Dawley Rats
Heart Diseases
Collagen

Keywords

  • Apoptosis
  • Hypertrophy
  • Obesity
  • PCNA
  • Renin angiotensin system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Cellular and ras changes in the hearts of young obese rats. / Ha, Kee Soo; Yoo, Kee Hwan; Yim, Hyung-Eun; Jang, Giyoung; Bae, In Sun; Hong, Young Sook; Lee, Joo Won.

In: Pediatric Cardiology, Vol. 32, No. 5, 01.06.2011, p. 659-666.

Research output: Contribution to journalArticle

Ha, Kee Soo ; Yoo, Kee Hwan ; Yim, Hyung-Eun ; Jang, Giyoung ; Bae, In Sun ; Hong, Young Sook ; Lee, Joo Won. / Cellular and ras changes in the hearts of young obese rats. In: Pediatric Cardiology. 2011 ; Vol. 32, No. 5. pp. 659-666.
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