Cellular flavonoid transport mechanisms in animal and plant cells

Yoo Li Han, So Young Lee, Ji Hae Lee, Sung-Joon Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Flavonoids have various biological activities; however, their cellular uptake mechanism is beginning to be understood only recently. This review focuses on cellular flavonoids transport mechanisms in both plants and animals. In plants, flavonoids exist in various cellular compartments, providing a specialized transport system. Newly synthesized flavonoids can be transported from the endoplasmic reticulum to the vacuoles or extracellular space via cellular trafficking pathway. Among membrane transporters, ATP binding cassette, multidrug and toxic extrusion, bilitranslocase homologue transporters play roles in both the influx and efflux of cellular flavonoids across the cell membrane. In recent years, extensive researches have provided a better understanding on the cellular flavonoid transport in mammalian cells. Bilitranslocase transports flavonoids in various tissues, including the liver, intestine and kidneys. However, other transport mechanisms are largely unknown and thus, further investigation should provide detailed mechanisms, which can potentially lead to an improved bioavailability and cellular function of flavonoids in humans.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalKorean Journal of Food Science and Technology
Volume45
Issue number2
DOIs
Publication statusPublished - 2013 Apr 28

Fingerprint

Plant Cells
Flavonoids
flavonoids
animals
cells
ABC transporters
Membrane Transport Proteins
extracellular space
Poisons
Extracellular Space
Vacuoles
extrusion
Endoplasmic Reticulum
endoplasmic reticulum
Biological Availability
Intestines
vacuoles
cell membranes
transporters
bioavailability

Keywords

  • Animal cell
  • Flavonoid
  • Plant cell
  • Transport
  • Transporter

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Cellular flavonoid transport mechanisms in animal and plant cells. / Han, Yoo Li; Lee, So Young; Lee, Ji Hae; Lee, Sung-Joon.

In: Korean Journal of Food Science and Technology, Vol. 45, No. 2, 28.04.2013, p. 137-141.

Research output: Contribution to journalArticle

Han, Yoo Li ; Lee, So Young ; Lee, Ji Hae ; Lee, Sung-Joon. / Cellular flavonoid transport mechanisms in animal and plant cells. In: Korean Journal of Food Science and Technology. 2013 ; Vol. 45, No. 2. pp. 137-141.
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