Cellular uptake of folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles

Kyoungja Woo; Jihyung Moon; Kyu Sil Choi; Tae Yeon Seong; Kwon Ha Yoon

doi:10.1016/j.jmmm.2009.02.096

Cellular uptake of folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles

Kyoungja Woo, Jihyung Moon, Kyu Sil Choi, Tae Yeon Seong, Kwon Ha Yoon

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We prepared five folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles (F₅-Liposuperparamagnetic iron oxide nanoparticles(SPIONs), 5.5 and 11 nm) and investigated their cellular uptake with KB cells, which is one of the representative folate-receptor over-expressing human epidermoid carcinoma cells, using MRI. The cellular uptake tests with the respective 5.5 and 11 nm F₅-LipoSPIONs at a fixed particle concentration showed appreciable amount of receptor-mediated uptakes and the specificity was higher in 5.5 nm SPIONs, due to its higher folic acid (FA) density, without inhibition. However, the numbers of the particles taken up under FA inhibition were similar, irrespective of their sizes.

Original language	English
Pages (from-to)	1610-1612
Number of pages	3
Journal	Journal of Magnetism and Magnetic Materials
Volume	321
Issue number	10
DOIs	https://doi.org/10.1016/j.jmmm.2009.02.096
Publication status	Published - 2009 May

Keywords

Cellular uptake
Folate-conjugated
Lipophilic
MRI
SPION
Surface modification

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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title = "Cellular uptake of folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles",

abstract = "We prepared five folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles (F5-Liposuperparamagnetic iron oxide nanoparticles(SPIONs), 5.5 and 11 nm) and investigated their cellular uptake with KB cells, which is one of the representative folate-receptor over-expressing human epidermoid carcinoma cells, using MRI. The cellular uptake tests with the respective 5.5 and 11 nm F5-LipoSPIONs at a fixed particle concentration showed appreciable amount of receptor-mediated uptakes and the specificity was higher in 5.5 nm SPIONs, due to its higher folic acid (FA) density, without inhibition. However, the numbers of the particles taken up under FA inhibition were similar, irrespective of their sizes.",

keywords = "Cellular uptake, Folate-conjugated, Lipophilic, MRI, SPION, Surface modification",

author = "Kyoungja Woo and Jihyung Moon and Choi, {Kyu Sil} and Seong, {Tae Yeon} and Yoon, {Kwon Ha}",

note = "Funding Information: The authors are thankful for financial support from the Korean Ministry of Education, Science and Technology through Grant no. 2007-02502 of the “Nano R&D Program” and “Future Key Technology Program”. ",

year = "2009",

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doi = "10.1016/j.jmmm.2009.02.096",

language = "English",

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T1 - Cellular uptake of folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles

AU - Woo, Kyoungja

AU - Moon, Jihyung

AU - Choi, Kyu Sil

AU - Seong, Tae Yeon

AU - Yoon, Kwon Ha

N1 - Funding Information: The authors are thankful for financial support from the Korean Ministry of Education, Science and Technology through Grant no. 2007-02502 of the “Nano R&D Program” and “Future Key Technology Program”.

PY - 2009/5

Y1 - 2009/5

N2 - We prepared five folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles (F5-Liposuperparamagnetic iron oxide nanoparticles(SPIONs), 5.5 and 11 nm) and investigated their cellular uptake with KB cells, which is one of the representative folate-receptor over-expressing human epidermoid carcinoma cells, using MRI. The cellular uptake tests with the respective 5.5 and 11 nm F5-LipoSPIONs at a fixed particle concentration showed appreciable amount of receptor-mediated uptakes and the specificity was higher in 5.5 nm SPIONs, due to its higher folic acid (FA) density, without inhibition. However, the numbers of the particles taken up under FA inhibition were similar, irrespective of their sizes.

AB - We prepared five folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles (F5-Liposuperparamagnetic iron oxide nanoparticles(SPIONs), 5.5 and 11 nm) and investigated their cellular uptake with KB cells, which is one of the representative folate-receptor over-expressing human epidermoid carcinoma cells, using MRI. The cellular uptake tests with the respective 5.5 and 11 nm F5-LipoSPIONs at a fixed particle concentration showed appreciable amount of receptor-mediated uptakes and the specificity was higher in 5.5 nm SPIONs, due to its higher folic acid (FA) density, without inhibition. However, the numbers of the particles taken up under FA inhibition were similar, irrespective of their sizes.

KW - Cellular uptake

KW - Folate-conjugated

KW - Lipophilic

KW - MRI

KW - SPION

KW - Surface modification

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IS - 10

ER -

Cellular uptake of folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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