Cellular uptake of folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles

Kyoungja Woo, Jihyung Moon, Kyu Sil Choi, Tae Yeon Seong, Kwon Ha Yoon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We prepared five folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles (F5-Liposuperparamagnetic iron oxide nanoparticles(SPIONs), 5.5 and 11 nm) and investigated their cellular uptake with KB cells, which is one of the representative folate-receptor over-expressing human epidermoid carcinoma cells, using MRI. The cellular uptake tests with the respective 5.5 and 11 nm F5-LipoSPIONs at a fixed particle concentration showed appreciable amount of receptor-mediated uptakes and the specificity was higher in 5.5 nm SPIONs, due to its higher folic acid (FA) density, without inhibition. However, the numbers of the particles taken up under FA inhibition were similar, irrespective of their sizes.

Original languageEnglish
Pages (from-to)1610-1612
Number of pages3
JournalJournal of Magnetism and Magnetic Materials
Volume321
Issue number10
DOIs
Publication statusPublished - 2009 May

Keywords

  • Cellular uptake
  • Folate-conjugated
  • Lipophilic
  • MRI
  • SPION
  • Surface modification

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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