Central Nervous System and its Disease Models on a Chip

YoonYoung Yi, JiSoo Park, Jaeho Lim, Changjoon Lee, Sang Hoon Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Technologies for microfluidics and biological microelectromechanical systems have been rapidly progressing over the past decade, enabling the development of unique microplatforms for in vitro human central nervous system (CNS) and related disease models. Most fundamental techniques include manipulation of axons, synapses, and neuronal networks, and different culture conditions are possible, such as compartmental, co-culturing, and 3D. Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms. In this review, we summarize fundamental technologies and current existing CNS disease models on microplatforms. We also discuss possible future directions, including application of these methods to pathological studies, drug screening, and personalized medicine, with 3D and personalized disease models that could generate more realistic CNS disease models. Various microplatforms mimicking in vivo microenvironments of central nervous system (CNS) are reviewed.In vitro CNS disease models, including Alzheimer's disease, Parkinson's disease, and so on, using microplatforms are introduced.Future directions of in vitro CNS disease model based on microplatforms are described, including its application to pathology studies, drug screening, and personalized medicine.

Original languageEnglish
Pages (from-to)762-776
Number of pages15
JournalTrends in Biotechnology
Volume33
Issue number12
DOIs
Publication statusPublished - 2015 Dec 1

    Fingerprint

Keywords

  • Brain
  • CNS
  • Microfluidics
  • Neural disease
  • Organ-on-a-chip

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Cite this