TY - JOUR
T1 - Cerebral amyloid accumulation is associated with distinct structural and functional alterations in the brain of depressed elders with mild cognitive impairment
AU - Hyung, Won Seok William
AU - Kang, June
AU - Kim, Junhyung
AU - Lee, Suji
AU - Youn, Hyun Chul
AU - Ham, Byung Joo
AU - Han, Changsu
AU - Suh, Sang-Il
AU - Han, Cheol E.
AU - Jeong, Hyun-Ghang
N1 - Funding Information:
This work was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) that was funded by the Ministry of Health & Welfare, Republic of Korea (HG Jeong, HC15C1509, HG Jeong & CE Han, HI19C0645); the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (HG Jeong, NRF-2015R1C1A1A01052172). None.
Funding Information:
This work was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) that was funded by the Ministry of Health & Welfare, Republic of Korea (HG Jeong, HC15C1509, HG Jeong & CE Han, HI19C0645); the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (HG Jeong, NRF-2015R1C1A1A01052172).
Publisher Copyright:
© 2020
PY - 2021/2/15
Y1 - 2021/2/15
N2 - Background: Elderly patients with late-life depression (LLD) often report mild cognitive impairment (MCI), so Alzheimer's disease (AD) is hard to identify in these patients. We aimed to identify the structural and functional differences between prodromal AD and LLD-related MCI. Methods: We performed voxel-based morphometry and functional connectivity (FC) analyses in elderly patients with both LLD and MCI to compare alterations between those with cerebral amyloidopathy and those without. We subdivided patients into subthreshold depression (STD) and major depressive disorder (MDD) groups. Using florbetaben positron emission tomography (PET), we compared volume and connectivity between healthy controls and four STD and MDD groups with or without amyloid deposition(A): STD-MCI-A(+), MDD-MCI-A(+), STD-MCI-A(-), and MDD-MCI-A(-). Results: Subjects with MDD or amyloid deposition showed greater volume reduction in the left middle temporal gyrus. MDD groups had lower FC than STD groups in the frontal, cortical, and limbic areas. The STD-MCI-A(+) group showed greater FC reduction than the MDD-MCI-A(-) and STD-MCI-A(-) groups, particularly in the hippocampus, parahippocampus, and frontal and temporal cortices. The functional differences associated with amyloid plaques were more evident in the STD group than in the MDD group. Limitations: Limitations include disproportional sex ratios, inability to determine the longitudinal effects of amyloidopathy in large populations. Conclusions: Regional gray matter loss and alterations in brain networks may reflect impairments caused by amyloid deposition and depression. Such changes may facilitate the detection of prodromal AD in elderly patients with both depression and cognitive dysfunction, allowing earlier intervention and more appropriate treatment.
AB - Background: Elderly patients with late-life depression (LLD) often report mild cognitive impairment (MCI), so Alzheimer's disease (AD) is hard to identify in these patients. We aimed to identify the structural and functional differences between prodromal AD and LLD-related MCI. Methods: We performed voxel-based morphometry and functional connectivity (FC) analyses in elderly patients with both LLD and MCI to compare alterations between those with cerebral amyloidopathy and those without. We subdivided patients into subthreshold depression (STD) and major depressive disorder (MDD) groups. Using florbetaben positron emission tomography (PET), we compared volume and connectivity between healthy controls and four STD and MDD groups with or without amyloid deposition(A): STD-MCI-A(+), MDD-MCI-A(+), STD-MCI-A(-), and MDD-MCI-A(-). Results: Subjects with MDD or amyloid deposition showed greater volume reduction in the left middle temporal gyrus. MDD groups had lower FC than STD groups in the frontal, cortical, and limbic areas. The STD-MCI-A(+) group showed greater FC reduction than the MDD-MCI-A(-) and STD-MCI-A(-) groups, particularly in the hippocampus, parahippocampus, and frontal and temporal cortices. The functional differences associated with amyloid plaques were more evident in the STD group than in the MDD group. Limitations: Limitations include disproportional sex ratios, inability to determine the longitudinal effects of amyloidopathy in large populations. Conclusions: Regional gray matter loss and alterations in brain networks may reflect impairments caused by amyloid deposition and depression. Such changes may facilitate the detection of prodromal AD in elderly patients with both depression and cognitive dysfunction, allowing earlier intervention and more appropriate treatment.
KW - Amyloid accumulation
KW - Late-life depression
KW - Mild cognitive impairment
KW - Resting-state functional connectivity
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=85098085524&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2020.12.049
DO - 10.1016/j.jad.2020.12.049
M3 - Article
C2 - 33360748
AN - SCOPUS:85098085524
VL - 281
SP - 459
EP - 466
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -