Cerebral perfusion abnormality in narcolepsy with cataplexy

Yeon Joo Eun, Seung Bong Hong, Suk Tae Woo, Hyun Kim Jee, Jung Han Sun, Won Cho Yong, Ho Yoon Chang, Ik Lee Sung, Hyung Lee Mann, Han Lee Kyung, Myoung Hee Kim, Tae Kim Byung, Leen Kim

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


To investigate abnormal cerebral perfusion in narcoleptics with cataplexy, 25 narcoleptics with cataplexy and 25 normal controls were enrolled in this study. Cerebral perfusion was measured by brain single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer. Patients and normal controls had not received any medication prior to the SPECT scan. Differences in cerebral perfusion between narcoleptics and normal controls were subjected to statistical parametric mapping (SPM) analysis. Overnight polysomnography and multiple sleep latency test (MSLT) were performed in all patients. Brain SPECT was carried out on all patients and normal controls during the waking state. Clinical symptoms and MSLT results of all patients are in accord with the International Classification of Sleep Disorders criteria for narcolepsy. MSLT showed a short mean sleep latency (1.69 ± 1.0 min) and 2-5 sleep onset REM periods in individual patient. SPM analysis of brain SPECT showed hypoperfusion of the bilateral anterior hypothalami, caudate nuclei, and pulvinar nuclei of thalami, parts of the dorsolateral/ventromedial prefrontal cortices, parahippocampal gyri, and cingulate gyri in narcoleptics [P < 0.05 by Student's t test with false discovery rate (FDR) correction]. Significant hypoperfusion in the white matter of frontal and parietal lobes was also noted in narcoleptics. This study shows reduced cerebral perfusion in subcortical structures and cortical areas in narcoleptics. The distribution of abnormal cerebral perfusion is concordant with the pathway of the cerebral hypocretin system and may explain the characteristic features of narcolepsy, i.e., cataplexy, emotional lability, and attention deficit.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
Issue number2
Publication statusPublished - 2005 Nov 1
Externally publishedYes


  • Cerebral perfusion
  • Hypothalamus
  • Narcolepsy
  • Tc-ethylcysteinate dimer (ECD)

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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