Cerebral small vessel disease in branch retinal artery occlusion

Kwan Hyuk Cho, Chi Kyung Kim, Se Joon Woo, Kyu Hyung Park, Sang Jun Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

PURPOSE. We investigated the pathophysiology of branch retinal artery occlusion (BRAO) by evaluating the retina, brain, and carotid artery in patients with BRAO. METHODS. This study was a retrospective registry study. We used 46 eyes from 46 patients with acute BRAO and evaluated the medical history, including previous cardiovascular disease, and compared brain magnetic resonance images (MRI) and carotid artery stenosis state between the embolic BRAO group and nonembolic BRAO group. We measured differences in cerebrovascular characteristics, including brain MRI, according to the existence of retinal emboli. RESULTS. The embolic BRAO group tended to have a significantly higher likelihood of cardiovascular disease history, including ischemic heart disease and smoking history (P = 0.018 and P < 0.001, respectively). In addition, the embolic group had a higher frequency of acute cerebral infarctions and stenotic carotid arteries (P = 0.017 and P = 0.028, respectively). Although the overall frequency of cerebral small vessel disease (SVD) did not differ between embolic and nonembolic groups, the nonembolic BRAO group showed a significantly higher prevalence of cerebral SVD without large vessel pathology (P = 0.008). CONCLUSIONS. Patients with BRAO showed different cerebrovascular characteristics following retinal emboli, including brain MRI findings. The results suggest that we must consider SVD etiology as well as large vessel disease mechanisms in the pathophysiology of BRAO.

Original languageEnglish
Pages (from-to)5818-5824
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number13
DOIs
Publication statusPublished - 2016 Oct 1

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Cerebral Small Vessel Diseases
Retinal Artery Occlusion
Magnetic Resonance Spectroscopy
Carotid Arteries
Brain
Cardiovascular Diseases
Intracranial Embolism
Carotid Stenosis
Cerebral Infarction
Embolism
Myocardial Ischemia
Registries
Retina
Retrospective Studies
Smoking
History

Keywords

  • Brain magnetic resonance image
  • Branch retinal artery occlusion
  • Cerebral small vessel disease
  • Retinal emboli

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Cerebral small vessel disease in branch retinal artery occlusion. / Cho, Kwan Hyuk; Kim, Chi Kyung; Woo, Se Joon; Park, Kyu Hyung; Park, Sang Jun.

In: Investigative Ophthalmology and Visual Science, Vol. 57, No. 13, 01.10.2016, p. 5818-5824.

Research output: Contribution to journalArticle

Cho, Kwan Hyuk ; Kim, Chi Kyung ; Woo, Se Joon ; Park, Kyu Hyung ; Park, Sang Jun. / Cerebral small vessel disease in branch retinal artery occlusion. In: Investigative Ophthalmology and Visual Science. 2016 ; Vol. 57, No. 13. pp. 5818-5824.
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