Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus

Dong Ju Kim, Emmanuel Carrera, Marek Czosnyka, Nicole Keong, Peter Smielewski, Oliveir Balédent, Michael P F Sutcliffe, John D. Pickard, Zofia Czosnyka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: The aim of the study was to develop a computational method for the assessment of brain pressure compensation of cerebrospinal arterial blood inflow. The method was verified using clinical recordings performed during infusion studies in a group of patients diagnosed with hydrocephalus. Materials and methods: We studied 27 patients suspected of having normal pressure hydrocephalus. The infusion test was used to measure the resistance to cerebrospinal fluid outflow, and the elastance coefficient was performed together with recording of the blood flow velocity in the middle cerebral artery. From the blood flow velocity waveform, the pulsatile pattern of increasing cerebral blood volume during one heart cycle was evaluated as a time integral of the arterial blood flow velocity minus the mean arterial blood flow. Cerebrospinal 'compliance index' (C i) was calculated as the amplitude of change in blood volume divided by the amplitude of intracranial pressure pulse waveform. Results: Compliance index C i decreased during the infusion test, proportionally inverse to the rise in intracranial pressure controlled by the external infusion of saline (R=-0.76; p<0.005). A relative change in compliance (from baseline to the plateau phase of the study) was positively associated with greater brain elasticity (R=0.61; p<0.005) and poorer compensatory reserve at the phase of infusion (R=0.51; p=0.009) Conclusion: C i decreases during the infusion study and seems to well replicate the relative changes in cerebrospinal compensatory reserve in hydrocephalus.

Original languageEnglish
Pages (from-to)587-592
Number of pages6
JournalNeurological Research
Volume32
Issue number6
DOIs
Publication statusPublished - 2010 Jul 1
Externally publishedYes

Fingerprint

Hydrocephalus
Compliance
Blood Flow Velocity
Intracranial Pressure
Normal Pressure Hydrocephalus
Elasticity
Middle Cerebral Artery
Brain
Blood Volume
Cerebrospinal Fluid
Cerebral Blood Volume
Pressure

Keywords

  • BRAIN
  • CEREBRAL BLOOD FLOW
  • CEREBROSPINAL COMPLIANCE INDEX
  • INTRACRANIAL PRESSURE
  • TCD MONITORING

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Kim, D. J., Carrera, E., Czosnyka, M., Keong, N., Smielewski, P., Balédent, O., ... Czosnyka, Z. (2010). Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus. Neurological Research, 32(6), 587-592. https://doi.org/10.1179/174313209X455673

Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus. / Kim, Dong Ju; Carrera, Emmanuel; Czosnyka, Marek; Keong, Nicole; Smielewski, Peter; Balédent, Oliveir; Sutcliffe, Michael P F; Pickard, John D.; Czosnyka, Zofia.

In: Neurological Research, Vol. 32, No. 6, 01.07.2010, p. 587-592.

Research output: Contribution to journalArticle

Kim, DJ, Carrera, E, Czosnyka, M, Keong, N, Smielewski, P, Balédent, O, Sutcliffe, MPF, Pickard, JD & Czosnyka, Z 2010, 'Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus', Neurological Research, vol. 32, no. 6, pp. 587-592. https://doi.org/10.1179/174313209X455673
Kim DJ, Carrera E, Czosnyka M, Keong N, Smielewski P, Balédent O et al. Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus. Neurological Research. 2010 Jul 1;32(6):587-592. https://doi.org/10.1179/174313209X455673
Kim, Dong Ju ; Carrera, Emmanuel ; Czosnyka, Marek ; Keong, Nicole ; Smielewski, Peter ; Balédent, Oliveir ; Sutcliffe, Michael P F ; Pickard, John D. ; Czosnyka, Zofia. / Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus. In: Neurological Research. 2010 ; Vol. 32, No. 6. pp. 587-592.
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