Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim, Taeho Kim, In Young Choi, Min Soh, Dohoung Kim, Young Ju Kim, Hyunduk Jang, Hye Sung Yang, Jun Yup Kim, Hong Kyun Park, Seung Pyo Park, Sangseung Park, Taekyung Yu, Byung Woo Yoon, Seung Hoon Lee, Taeghwan Hyeon

Research output: Contribution to journalArticlepeer-review

260 Citations (Scopus)

Abstract

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

Original languageEnglish
Pages (from-to)11039-11043
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number44
DOIs
Publication statusPublished - 2012 Oct 29
Externally publishedYes

Keywords

  • apoptosis
  • ceria nanoparticles
  • ischemic stroke
  • reactive oxygen species
  • therapeutic agents

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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