Abstract
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 11399-11403 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 56 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
| Externally published | Yes |
Fingerprint
Keywords
- ceria–zirconia nanoparticles
- inflammation
- reactive oxygen species
- sepsis
- therapeutic nanomedicine
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
Cite this
Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment. / Soh, Min; Kang, Dong Wan; Jeong, Han Gil; Kim, Dokyoon; Kim, Do Yeon; Yang, Wookjin; Song, Changyeong; Baik, Seungmin; Choi, In Young; Ki, Seul Ki; Kwon, Hyek Jin; Kim, Taeho; Kim, Chi Kyung; Lee, Seung Hoon; Hyeon, Taeghwan.
In: Angewandte Chemie - International Edition, Vol. 56, No. 38, 01.01.2017, p. 11399-11403.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment
AU - Soh, Min
AU - Kang, Dong Wan
AU - Jeong, Han Gil
AU - Kim, Dokyoon
AU - Kim, Do Yeon
AU - Yang, Wookjin
AU - Song, Changyeong
AU - Baik, Seungmin
AU - Choi, In Young
AU - Ki, Seul Ki
AU - Kwon, Hyek Jin
AU - Kim, Taeho
AU - Kim, Chi Kyung
AU - Lee, Seung Hoon
AU - Hyeon, Taeghwan
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.
AB - The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.
KW - ceria–zirconia nanoparticles
KW - inflammation
KW - reactive oxygen species
KW - sepsis
KW - therapeutic nanomedicine
UR - http://www.scopus.com/inward/record.url?scp=85021846361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021846361&partnerID=8YFLogxK
U2 - 10.1002/anie.201704904
DO - 10.1002/anie.201704904
M3 - Article
C2 - 28643857
AN - SCOPUS:85021846361
VL - 56
SP - 11399
EP - 11403
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 38
ER -