Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Min Soh, Dong Wan Kang, Han Gil Jeong, Dokyoon Kim, Do Yeon Kim, Wookjin Yang, Changyeong Song, Seungmin Baik, In Young Choi, Seul Ki Ki, Hyek Jin Kwon, Taeho Kim, Chi Kyung Kim, Seung Hoon Lee, Taeghwan Hyeon

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2 and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.

Original languageEnglish
Pages (from-to)11399-11403
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number38
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Keywords

  • ceria–zirconia nanoparticles
  • inflammation
  • reactive oxygen species
  • sepsis
  • therapeutic nanomedicine

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment'. Together they form a unique fingerprint.

  • Cite this

    Soh, M., Kang, D. W., Jeong, H. G., Kim, D., Kim, D. Y., Yang, W., Song, C., Baik, S., Choi, I. Y., Ki, S. K., Kwon, H. J., Kim, T., Kim, C. K., Lee, S. H., & Hyeon, T. (2017). Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment. Angewandte Chemie - International Edition, 56(38), 11399-11403. https://doi.org/10.1002/anie.201704904