Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Min Soh; Dong Wan Kang; Han Gil Jeong; Dokyoon Kim; Do Yeon Kim; Wookjin Yang; Changyeong Song; Seungmin Baik; In Young Choi; Seul Ki Ki; Hyek Jin Kwon; Taeho Kim; Chi Kyung Kim; Seung Hoon Lee; Taeghwan Hyeon

doi:10.1002/anie.201704904

Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Min Soh, Dong Wan Kang, Han Gil Jeong, Dokyoon Kim, Do Yeon Kim, Wookjin Yang, Changyeong Song, Seungmin Baik, In Young Choi, Seul Ki Ki, Hyek Jin Kwon, Taeho Kim, Chi Kyung Kim, Seung Hoon Lee, Taeghwan Hyeon

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

Abstract

The two oxidation states of ceria nanoparticles, Ce³⁺ and Ce⁴⁺, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce³⁺ is largely responsible for removing O₂⁻ and ^.OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce³⁺/Ce⁴⁺ ratio and faster conversion from Ce⁴⁺ to Ce³⁺ than those exhibited by ceria nanoparticles. The obtained Ce_0.7Zr_0.3O₂ (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.

Original language	English
Pages (from-to)	11399-11403
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	38
DOIs	https://doi.org/10.1002/anie.201704904
Publication status	Published - 2017 Sep 11
Externally published	Yes

Keywords

ceria–zirconia nanoparticles
inflammation
reactive oxygen species
sepsis
therapeutic nanomedicine

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment. / Soh, Min; Kang, Dong Wan; Jeong, Han Gil; Kim, Dokyoon; Kim, Do Yeon; Yang, Wookjin; Song, Changyeong; Baik, Seungmin; Choi, In Young; Ki, Seul Ki; Kwon, Hyek Jin; Kim, Taeho; Kim, Chi Kyung; Lee, Seung Hoon; Hyeon, Taeghwan.

In: Angewandte Chemie - International Edition, Vol. 56, No. 38, 11.09.2017, p. 11399-11403.

Research output: Contribution to journal › Article › peer-review

Soh, Min ; Kang, Dong Wan ; Jeong, Han Gil ; Kim, Dokyoon ; Kim, Do Yeon ; Yang, Wookjin ; Song, Changyeong ; Baik, Seungmin ; Choi, In Young ; Ki, Seul Ki ; Kwon, Hyek Jin ; Kim, Taeho ; Kim, Chi Kyung ; Lee, Seung Hoon ; Hyeon, Taeghwan. / Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment. In: Angewandte Chemie - International Edition. 2017 ; Vol. 56, No. 38. pp. 11399-11403.

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title = "Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment",

abstract = "The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.",

keywords = "ceria–zirconia nanoparticles, inflammation, reactive oxygen species, sepsis, therapeutic nanomedicine",

author = "Min Soh and Kang, {Dong Wan} and Jeong, {Han Gil} and Dokyoon Kim and Kim, {Do Yeon} and Wookjin Yang and Changyeong Song and Seungmin Baik and Choi, {In Young} and Ki, {Seul Ki} and Kwon, {Hyek Jin} and Taeho Kim and Kim, {Chi Kyung} and Lee, {Seung Hoon} and Taeghwan Hyeon",

note = "Funding Information: This work was supported by Institute for Basic Science (IBS) in Korea (IBS-R006-D1), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare (HI14C0211), and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1A2A2A01007770). Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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AU - Soh, Min

AU - Kang, Dong Wan

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AU - Kim, Dokyoon

AU - Kim, Do Yeon

AU - Yang, Wookjin

AU - Song, Changyeong

AU - Baik, Seungmin

AU - Choi, In Young

AU - Ki, Seul Ki

AU - Kwon, Hyek Jin

AU - Kim, Taeho

AU - Kim, Chi Kyung

AU - Lee, Seung Hoon

AU - Hyeon, Taeghwan

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PY - 2017/9/11

Y1 - 2017/9/11

N2 - The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.

AB - The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.

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Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Abstract

Keywords

ASJC Scopus subject areas

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