Change in functional networks for transitions between states of consciousness during midazolam-induced sedation

Minji Lee, Robert D. Sanders, Seul Ki Yeom, Dong Ok Won, Hwi Jae Kim, Bo Ram Lee, Kwang Suk Seo, Hyun Jeong Kim, Giulio Tononi, Seong Whan Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

How brain dynamics change across conscious states, including reliable signatures of the transitions between unconsciousness and consciousness, remains unclear. In this work, we addressed the changes in functional brain networks during self-titrated midazolam sedation using high-density electroencephalography (EEG) in ten subjects. We were particularly interested in the underlying network alterations, identified with graph theory, associated with transitions between states of consciousness. The weighted Phase Lag Index (wPLI) was used as the connectivity estimator between two signals. Based on wPLI, we calculated network properties such as characteristic path length, clustering coefficient, and small-worldness for measuring the integration and segregation of the brain network. We found significant changes in power and wPLI at different levels of consciousness. During unconsciousness, wPLI over the parietal region was higher in the delta band (1-4Hz). The frontal-parietal interaction in the delta band was also stronger during the transition from consciousness to unconsciousness. There was the significant difference of wPLI over the frontal region between consciousness and unconsciousness in the sigma band (12-15Hz). The topological properties across conscious states were significantly changed in the delta band and sigma band. Our results showed parietal brain dynamics is associated with consciousness. Our data also suggest that reversible changes in delta power and connectivity underlie changes in conscious state.

Original languageEnglish
Title of host publication2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages958-961
Number of pages4
ISBN (Electronic)9781509028092
DOIs
Publication statusPublished - 2017 Sep 13
Externally publishedYes
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: 2017 Jul 112017 Jul 15

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
CountryKorea, Republic of
CityJeju Island
Period17/7/1117/7/15

Fingerprint

Midazolam
Consciousness
Brain
Unconsciousness
Graph theory
Electroencephalography
Parietal Lobe
Cluster Analysis

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Lee, M., Sanders, R. D., Yeom, S. K., Won, D. O., Kim, H. J., Lee, B. R., ... Lee, S. W. (2017). Change in functional networks for transitions between states of consciousness during midazolam-induced sedation. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings (pp. 958-961). [8036984] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2017.8036984

Change in functional networks for transitions between states of consciousness during midazolam-induced sedation. / Lee, Minji; Sanders, Robert D.; Yeom, Seul Ki; Won, Dong Ok; Kim, Hwi Jae; Lee, Bo Ram; Seo, Kwang Suk; Kim, Hyun Jeong; Tononi, Giulio; Lee, Seong Whan.

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. p. 958-961 8036984 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lee, M, Sanders, RD, Yeom, SK, Won, DO, Kim, HJ, Lee, BR, Seo, KS, Kim, HJ, Tononi, G & Lee, SW 2017, Change in functional networks for transitions between states of consciousness during midazolam-induced sedation. in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8036984, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 958-961, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 17/7/11. https://doi.org/10.1109/EMBC.2017.8036984
Lee M, Sanders RD, Yeom SK, Won DO, Kim HJ, Lee BR et al. Change in functional networks for transitions between states of consciousness during midazolam-induced sedation. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. p. 958-961. 8036984. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2017.8036984
Lee, Minji ; Sanders, Robert D. ; Yeom, Seul Ki ; Won, Dong Ok ; Kim, Hwi Jae ; Lee, Bo Ram ; Seo, Kwang Suk ; Kim, Hyun Jeong ; Tononi, Giulio ; Lee, Seong Whan. / Change in functional networks for transitions between states of consciousness during midazolam-induced sedation. 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 958-961 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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