Change in kidney damage biomarkers after 13weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae

Mihye Jeong, Young Won Kim, Jeong Ran Min, Min Kwon, Beom Suk Han, Jeong-Gyu Kim, Sang Hee Jeong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Complex of Paecilomyces sinclairii and host larvae, Bombyx mori, is a well known health food; however, concerns about nephrotoxicity have been raised. Kidney toxicity was investigated after 13. weeks of administering the complex orally to rats with parameters including blood urea nitrogen (BUN), creatinine, and kidney damage biomarkers, beta-2-microglobulin (β2m), glutathione S-transferase alpha (GST-α), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), and osteopontin. Dose-dependent kidney cell karyomegaly and tubular hypertrophy were observed, with higher severity in males. There was a dose-dependent increase in KIM-1 and TIMP-1 levels in kidney and urinary KIM-1, cystatin C, β2m, and osteopontin levels. KIM-1 and TIMP-1 increased in male kidneys had not recovered by 2. weeks after stopping exposure. Cystatin C in kidney was significantly lowered in all treatment groups at 13. weeks of administration. All the changes were more noticeable in males. These data indicate that the complex damage renal tubule cells with histopathological lesions and changes in biomarker levels. Kidney and urinary KIM-1 and cystatin C were the most markedly affected and early increased indicators among biomarkers tested, whereas BUN and creatinine were not affected.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalFood and Chemical Toxicology
Volume59
DOIs
Publication statusPublished - 2013 Sep 1

Fingerprint

Paecilomyces
Bombyx
Biomarkers
Bombyx mori
Cystatin C
Larva
Rats
biomarkers
Matrix Metalloproteinase 1
kidneys
Kidney
Molecules
larvae
rats
cystatins
Osteopontin
Tissue
interstitial collagenase
Urea
Creatinine

Keywords

  • Bombyx mori larvae
  • Cystatin C
  • Kidney damage biomarkers
  • Kidney injury molecule 1
  • Kidney toxicity
  • Paecilomyces sinclairii

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Change in kidney damage biomarkers after 13weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae. / Jeong, Mihye; Kim, Young Won; Min, Jeong Ran; Kwon, Min; Han, Beom Suk; Kim, Jeong-Gyu; Jeong, Sang Hee.

In: Food and Chemical Toxicology, Vol. 59, 01.09.2013, p. 177-186.

Research output: Contribution to journalArticle

Jeong, Mihye ; Kim, Young Won ; Min, Jeong Ran ; Kwon, Min ; Han, Beom Suk ; Kim, Jeong-Gyu ; Jeong, Sang Hee. / Change in kidney damage biomarkers after 13weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae. In: Food and Chemical Toxicology. 2013 ; Vol. 59. pp. 177-186.
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