Change of connexin 37 in allergen-induced airway inflammation

Ju Park Seoung, Sun Lee Kyung, Ri Kim So, Kyung-Hoon Min, Young Lee Ka, Hun Choe Yeong, Yong Park Seung, Hyun Hong Sang, Chul Lee Yong

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Gap junction channels formed with connexins directly link to the cytoplasm of adjacent cells and have been implicated in intercellular signaling. Connexin 37 (Cx37) is expressed in the gas-exchange region of the lung. Recently, Cx37 has been reported to be involved in the pathogenesis of inflammatory disease. However, no data are available on the role of Cx37 in allergic airway inflammatory disease. In the present study, we used a murine model of ovalbumin (OVA)-induced allergic airway disease and primary murine epithelial cells to examine the change of Cx37 in allergic airway disease. These mice develop the following typical pathophysiological features of asthma: airway hyperresponsiveness, airway inflammation, and increased IL-4, IL-5, IL-13, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, eotaxin, and RANTES levels in lungs. Cx37 protein and mRNA expression were decreased in OVA-induced allergic airway disease. Immunoreactive Cx37 localized in epithelial layers around the bronchioles in control mice, which dramatically disappeared in allergen-induced asthmatic lungs. Moreover, the levels of Cx37 protein in lung tissues showed significantly negative correlations with airway inflammation, airway responsiveness, and levels of Th2 cytokines in lungs. These findings indicate that change of Cx37 may be associated with the asthma phenotype.

Original languageEnglish
Pages (from-to)629-640
Number of pages12
JournalExperimental and Molecular Medicine
Volume39
Issue number5
Publication statusPublished - 2007 Oct 31
Externally publishedYes

Fingerprint

Allergens
Inflammation
Lung
Ovalbumin
Asthma
Bronchioles
Chemokine CCL5
Connexins
Interleukin-13
Vascular Cell Adhesion Molecule-1
connexin 37
Gap Junctions
Interleukin-5
Intercellular Adhesion Molecule-1
Interleukin-4
Cytoplasm
Proteins
Gases
Epithelial Cells
Tissue

Keywords

  • Asthma
  • Connexin 37
  • Epithelial cells
  • Gap junctions
  • Inflammation mediators
  • Models, animal
  • Respiratory system

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Seoung, J. P., Kyung, S. L., So, R. K., Min, K-H., Ka, Y. L., Yeong, H. C., ... Yong, C. L. (2007). Change of connexin 37 in allergen-induced airway inflammation. Experimental and Molecular Medicine, 39(5), 629-640.

Change of connexin 37 in allergen-induced airway inflammation. / Seoung, Ju Park; Kyung, Sun Lee; So, Ri Kim; Min, Kyung-Hoon; Ka, Young Lee; Yeong, Hun Choe; Seung, Yong Park; Sang, Hyun Hong; Yong, Chul Lee.

In: Experimental and Molecular Medicine, Vol. 39, No. 5, 31.10.2007, p. 629-640.

Research output: Contribution to journalArticle

Seoung, JP, Kyung, SL, So, RK, Min, K-H, Ka, YL, Yeong, HC, Seung, YP, Sang, HH & Yong, CL 2007, 'Change of connexin 37 in allergen-induced airway inflammation', Experimental and Molecular Medicine, vol. 39, no. 5, pp. 629-640.
Seoung JP, Kyung SL, So RK, Min K-H, Ka YL, Yeong HC et al. Change of connexin 37 in allergen-induced airway inflammation. Experimental and Molecular Medicine. 2007 Oct 31;39(5):629-640.
Seoung, Ju Park ; Kyung, Sun Lee ; So, Ri Kim ; Min, Kyung-Hoon ; Ka, Young Lee ; Yeong, Hun Choe ; Seung, Yong Park ; Sang, Hyun Hong ; Yong, Chul Lee. / Change of connexin 37 in allergen-induced airway inflammation. In: Experimental and Molecular Medicine. 2007 ; Vol. 39, No. 5. pp. 629-640.
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