Changes in Drosophila melanogaster Sleep-Wake Behavior Due to Lotus (Nelumbo nucifera) Seed and Hwang Jeong (Polygonatum sibiricum) Extracts

Kyungae Jo, Sang Duk Jeon, Chang Won Ahn, Sung Hee Han, Hyung Joo Suh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We evaluated the sleep enhancement activity of the medicinal herbs valerian (Valeriana officinalis), jujube (Ziziphus jujube), lotus seed (Nelumbo nucifera), Gastrodia elata, Polygonatum sibiricum, and baekbokryung (Poria cocos), which can relieve insomnia in a Drosophila model. Locomotor activity was measured in the Drosophila model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of P. sibiricum significantly reduced nocturnal activity compared to the control group (P<0.05). The activity and sleep bouts of fruit flies were significantly decreased by a high-dose treatment (10 mg/mL) of lotus or P. sibiricum extracts at night. Caffeine-treated Drosophila showed increased nocturnal activity and decreased total sleep time (P<0.05). Flies receiving the 10 mg-doses of lotus seed or P. sibiricum extract showed significantly different nocturnal locomotor activity and total sleep time compared to caffeine-treated Drosophila. Lotus seed and P. sibiricum extracts are attractive and valuable sleep-potentiating nutraceuticals.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalPreventive Nutrition and Food Science
Volume22
Issue number4
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Polygonatum sibiricum
Polygonatum
Nelumbo
Nelumbo nucifera
Lotus
sleep
Drosophila melanogaster
Seeds
Sleep
Ziziphus
extracts
nocturnal activity
Drosophila
seeds
Locomotion
Medicinal Plants
caffeine
Caffeine
Diptera
locomotion

Keywords

  • Drosophila melanogaster
  • Nelumbo nucifera
  • Polygonatum sibiricum
  • Sleep

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Changes in Drosophila melanogaster Sleep-Wake Behavior Due to Lotus (Nelumbo nucifera) Seed and Hwang Jeong (Polygonatum sibiricum) Extracts. / Jo, Kyungae; Jeon, Sang Duk; Ahn, Chang Won; Han, Sung Hee; Suh, Hyung Joo.

In: Preventive Nutrition and Food Science, Vol. 22, No. 4, 01.12.2017, p. 293-299.

Research output: Contribution to journalArticle

@article{ebd78085a8844f3aa84ef7eb89b531b1,
title = "Changes in Drosophila melanogaster Sleep-Wake Behavior Due to Lotus (Nelumbo nucifera) Seed and Hwang Jeong (Polygonatum sibiricum) Extracts",
abstract = "We evaluated the sleep enhancement activity of the medicinal herbs valerian (Valeriana officinalis), jujube (Ziziphus jujube), lotus seed (Nelumbo nucifera), Gastrodia elata, Polygonatum sibiricum, and baekbokryung (Poria cocos), which can relieve insomnia in a Drosophila model. Locomotor activity was measured in the Drosophila model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of P. sibiricum significantly reduced nocturnal activity compared to the control group (P<0.05). The activity and sleep bouts of fruit flies were significantly decreased by a high-dose treatment (10 mg/mL) of lotus or P. sibiricum extracts at night. Caffeine-treated Drosophila showed increased nocturnal activity and decreased total sleep time (P<0.05). Flies receiving the 10 mg-doses of lotus seed or P. sibiricum extract showed significantly different nocturnal locomotor activity and total sleep time compared to caffeine-treated Drosophila. Lotus seed and P. sibiricum extracts are attractive and valuable sleep-potentiating nutraceuticals.",
keywords = "Drosophila melanogaster, Nelumbo nucifera, Polygonatum sibiricum, Sleep",
author = "Kyungae Jo and Jeon, {Sang Duk} and Ahn, {Chang Won} and Han, {Sung Hee} and Suh, {Hyung Joo}",
year = "2017",
month = "12",
day = "1",
doi = "10.3746/pnf.2017.22.4.293",
language = "English",
volume = "22",
pages = "293--299",
journal = "Preventive Nutrition and Food Science",
issn = "2287-1098",
publisher = "Korean Society of Food Science and Nutrition",
number = "4",

}

TY - JOUR

T1 - Changes in Drosophila melanogaster Sleep-Wake Behavior Due to Lotus (Nelumbo nucifera) Seed and Hwang Jeong (Polygonatum sibiricum) Extracts

AU - Jo, Kyungae

AU - Jeon, Sang Duk

AU - Ahn, Chang Won

AU - Han, Sung Hee

AU - Suh, Hyung Joo

PY - 2017/12/1

Y1 - 2017/12/1

N2 - We evaluated the sleep enhancement activity of the medicinal herbs valerian (Valeriana officinalis), jujube (Ziziphus jujube), lotus seed (Nelumbo nucifera), Gastrodia elata, Polygonatum sibiricum, and baekbokryung (Poria cocos), which can relieve insomnia in a Drosophila model. Locomotor activity was measured in the Drosophila model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of P. sibiricum significantly reduced nocturnal activity compared to the control group (P<0.05). The activity and sleep bouts of fruit flies were significantly decreased by a high-dose treatment (10 mg/mL) of lotus or P. sibiricum extracts at night. Caffeine-treated Drosophila showed increased nocturnal activity and decreased total sleep time (P<0.05). Flies receiving the 10 mg-doses of lotus seed or P. sibiricum extract showed significantly different nocturnal locomotor activity and total sleep time compared to caffeine-treated Drosophila. Lotus seed and P. sibiricum extracts are attractive and valuable sleep-potentiating nutraceuticals.

AB - We evaluated the sleep enhancement activity of the medicinal herbs valerian (Valeriana officinalis), jujube (Ziziphus jujube), lotus seed (Nelumbo nucifera), Gastrodia elata, Polygonatum sibiricum, and baekbokryung (Poria cocos), which can relieve insomnia in a Drosophila model. Locomotor activity was measured in the Drosophila model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of P. sibiricum significantly reduced nocturnal activity compared to the control group (P<0.05). The activity and sleep bouts of fruit flies were significantly decreased by a high-dose treatment (10 mg/mL) of lotus or P. sibiricum extracts at night. Caffeine-treated Drosophila showed increased nocturnal activity and decreased total sleep time (P<0.05). Flies receiving the 10 mg-doses of lotus seed or P. sibiricum extract showed significantly different nocturnal locomotor activity and total sleep time compared to caffeine-treated Drosophila. Lotus seed and P. sibiricum extracts are attractive and valuable sleep-potentiating nutraceuticals.

KW - Drosophila melanogaster

KW - Nelumbo nucifera

KW - Polygonatum sibiricum

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=85040335092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040335092&partnerID=8YFLogxK

U2 - 10.3746/pnf.2017.22.4.293

DO - 10.3746/pnf.2017.22.4.293

M3 - Article

AN - SCOPUS:85040335092

VL - 22

SP - 293

EP - 299

JO - Preventive Nutrition and Food Science

JF - Preventive Nutrition and Food Science

SN - 2287-1098

IS - 4

ER -