Changes in sexual function and gonadal axis hormones after switching to aripiprazole in male schizophrenia patients

A prospective pilot study

Hyun-Ghang Jeong, Moon-Soo Lee, Hwa Young Lee, Young-Hoon Ko, Changsu Han, Sook Haeng Joe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Antipsychotic-induced sexual dysfunction is a common problem in patients with schizophrenia. The aim of the study was to investigate the effect of switching to aripiprazole on sexual dysfunction and the hypothalamic-pituitary- gonadal axis in male patients with schizophrenia. In this prospective, open-label study, the participants were 10 male schizophrenia patients treated with atypical antipsychotics, risperidone, amisulpride, and olanzapine. Before and after switching to aripiprazole, they were assessed on the Arizona Sexual Experience Scale, and hormonal levels were measured. Our results showed a significant improvement in the severity of sexual dysfunction, especially in 'ease of sexual arousal' and 'penile erection,' as measured by the Arizona Sexual Experience Scale total scores after switching to aripiprazole (χ 2=12.45 and P=0.002). The serum prolactin level decreased significantly after switching to aripiprazole (χ 2=11.14 and P=0.004), but the changes in the total testosterone level were not significant (χ 2=4.75 and P=0.93). Our results suggest that sexual dysfunction in schizophrenia patients seems to improve after switching to aripiprazole from other atypical antipsychotics (risperiodone, amisulpride, or olanzapine). This may be associated with a change in dopamine and serotonin transmissions and a decrease in the serum prolactin concentration.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalInternational Clinical Psychopharmacology
Volume27
Issue number4
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Gonadal Hormones
Schizophrenia
olanzapine
Prospective Studies
Antipsychotic Agents
Prolactin
Penile Erection
Risperidone
Arousal
Serum
Testosterone
Dopamine
Serotonin
Aripiprazole

Keywords

  • aripiprazole
  • atypical antipsychotics
  • erectile dysfunction
  • hypothalamic-pituitary-gonadal axis
  • prolactin
  • sexual sfunction
  • testosterone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

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abstract = "Antipsychotic-induced sexual dysfunction is a common problem in patients with schizophrenia. The aim of the study was to investigate the effect of switching to aripiprazole on sexual dysfunction and the hypothalamic-pituitary- gonadal axis in male patients with schizophrenia. In this prospective, open-label study, the participants were 10 male schizophrenia patients treated with atypical antipsychotics, risperidone, amisulpride, and olanzapine. Before and after switching to aripiprazole, they were assessed on the Arizona Sexual Experience Scale, and hormonal levels were measured. Our results showed a significant improvement in the severity of sexual dysfunction, especially in 'ease of sexual arousal' and 'penile erection,' as measured by the Arizona Sexual Experience Scale total scores after switching to aripiprazole (χ 2=12.45 and P=0.002). The serum prolactin level decreased significantly after switching to aripiprazole (χ 2=11.14 and P=0.004), but the changes in the total testosterone level were not significant (χ 2=4.75 and P=0.93). Our results suggest that sexual dysfunction in schizophrenia patients seems to improve after switching to aripiprazole from other atypical antipsychotics (risperiodone, amisulpride, or olanzapine). This may be associated with a change in dopamine and serotonin transmissions and a decrease in the serum prolactin concentration.",
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