Changes in sexual function and gonadal axis hormones after switching to aripiprazole in male schizophrenia patients: A prospective pilot study

Hyun Ghang Jeong, Moon Soo Lee, Hwa Young Lee, Young Hoon Ko, Changsu Han, Sook Haeng Joe

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Antipsychotic-induced sexual dysfunction is a common problem in patients with schizophrenia. The aim of the study was to investigate the effect of switching to aripiprazole on sexual dysfunction and the hypothalamic-pituitary- gonadal axis in male patients with schizophrenia. In this prospective, open-label study, the participants were 10 male schizophrenia patients treated with atypical antipsychotics, risperidone, amisulpride, and olanzapine. Before and after switching to aripiprazole, they were assessed on the Arizona Sexual Experience Scale, and hormonal levels were measured. Our results showed a significant improvement in the severity of sexual dysfunction, especially in 'ease of sexual arousal' and 'penile erection,' as measured by the Arizona Sexual Experience Scale total scores after switching to aripiprazole (χ 2=12.45 and P=0.002). The serum prolactin level decreased significantly after switching to aripiprazole (χ 2=11.14 and P=0.004), but the changes in the total testosterone level were not significant (χ 2=4.75 and P=0.93). Our results suggest that sexual dysfunction in schizophrenia patients seems to improve after switching to aripiprazole from other atypical antipsychotics (risperiodone, amisulpride, or olanzapine). This may be associated with a change in dopamine and serotonin transmissions and a decrease in the serum prolactin concentration.

    Original languageEnglish
    Pages (from-to)177-183
    Number of pages7
    JournalInternational clinical psychopharmacology
    Volume27
    Issue number4
    DOIs
    Publication statusPublished - 2012 Jul

    Keywords

    • aripiprazole
    • atypical antipsychotics
    • erectile dysfunction
    • hypothalamic-pituitary-gonadal axis
    • prolactin
    • sexual sfunction
    • testosterone

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Pharmacology (medical)

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