Changes in subcortical shape and cognitive function in patients with chronic insomnia

Dae Lim Koo, Jeong Hyeon Shin, Jae Sung Lim, Jun Kyung Seong, Eun Yeon Joo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective The aim of this study was to examine morphological changes in subcortical structures via surface-based analysis and to correlate local shape changes with cognitive function. Methods We analyzed subcortical brain morphology and compared the shape changes with clinical and neuropsychological features in patients with chronic insomnia. Results Hippocampal atrophy was associated with higher Pittsburgh Sleep Quality Index scores (r = −0.4, p = 0.0408) and higher arousal indices (r = −0.4, p = 0.0332). Local volume loss of the putamen was associated with higher arousal indices (r = −0.5, p = 0.0416). Atrophic change of subcortical structures including the hippocampus, amygdala, basal ganglia, and thalamus, correlated negatively with verbal fluency, frontal function, verbal memory, and visual memory, respectively, in these patients (|r| ≥ 0.3, p < 0.05). Conclusions This study shows that sleep quality and fragmentation are closely related to atrophic changes in hippocampus and putamen. In addition, atrophic changes in global subcortical structures are associated with impaired cognitive function in patients with chronic insomnia.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalSleep Medicine
Volume35
DOIs
Publication statusPublished - 2017 Jul 1

Fingerprint

Sleep Initiation and Maintenance Disorders
Cognition
Putamen
Arousal
Hippocampus
Sleep Deprivation
Amygdala
Basal Ganglia
Thalamus
Atrophy
Sleep
Brain

Keywords

  • Chronic insomnia
  • Cognitive function
  • Shape analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Changes in subcortical shape and cognitive function in patients with chronic insomnia. / Koo, Dae Lim; Shin, Jeong Hyeon; Lim, Jae Sung; Seong, Jun Kyung; Joo, Eun Yeon.

In: Sleep Medicine, Vol. 35, 01.07.2017, p. 23-26.

Research output: Contribution to journalArticle

Koo, Dae Lim ; Shin, Jeong Hyeon ; Lim, Jae Sung ; Seong, Jun Kyung ; Joo, Eun Yeon. / Changes in subcortical shape and cognitive function in patients with chronic insomnia. In: Sleep Medicine. 2017 ; Vol. 35. pp. 23-26.
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