Changes in the arginine methylation of organ proteins during the development of diabetes mellitus

Jong Hoon Lee, Gil Hong Park, Young Koo Lee, Jun Hyung Park

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Aim: In this study, we examined changes in asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide synthesis (NOS), and the arginine methylation of organ proteins during the development of diabetes in mice. Methods: Db/db mice developed significant obesity and fasting hyperglycemia during diabetogenesis. During diabetogenesis, the expression of ADMA and nNOS was increased, while that of DDAH1 and protein-arginine methyltransferase 1 (PRMT1) was decreased. Additionally, arginine methylation in the liver and adipose tissue was altered during diabetogenesis. Results: Changes were evident at 75, 60, and 52. kDa in liver tissue and at 38 and 25. kDa in adipose tissue. Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development. Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes.

    Original languageEnglish
    Pages (from-to)111-118
    Number of pages8
    JournalDiabetes Research and Clinical Practice
    Volume94
    Issue number1
    DOIs
    Publication statusPublished - 2011 Oct

    Keywords

    • Arginine methylation
    • Asymmetric dimethylarginine
    • Diabetes mellitus
    • Dimethylarginine dimethylaminohydrolase
    • Nitric oxide synthase

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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