Changes in the levels of insulin-like growth factors (IGF-I and IGF-II) in bovine milk according to the lactation period and parity

S. H. Kang, J. U. Kim, Y. Kim, K. S. Han, W. J. Lee, J. Y. Imm, S. Oh, D. J. Park, Y. I. Moon, Sae Hun Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The objectives of this study were to characterize the changes occurring in the levels of insulin-like growth factors (IGF-I and IGF-II) in bovine milk during a one-year lactation period, and to determine the parameters affecting IGF content in bovine milk. Milk was collected individually from lactating Holstein cows (n = 70), and IGF-I and -II levels were determined via radioimmunoassay, using 125I after acid-ethanol treatment. The proximate compositions of the milk samples were determined using a near-infrared milk analyzer. The data were analyzed by the GLM and CORR procedures using SAS software to determine significant differences (p<0.05) occurring within groups (dairy farms, lactation periods, season, and parity). We noted an approximately six-fold reduction in the IGF-I concentration (from 2,462.7 to 353.0 ng/ml) and a three-fold drop in the IGF-II concentration (from 929.1 to 365.7 ng/ml) in the bovine colostrum, between 6 h after parturition and 18 h after parturition. IGF-I and -II content, measured at the early, middle, and late stages of lactation did not change significantly throughout the entirety of the lactation period. Interestingly, parity did not significantly affect IGF-I content, but did significantly affect IGF-II content between the primiparous and multiparous cows. We also found there were no significant relationships between IGF-I and total protein content or somatic cell counts (p<0.05).

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalAsian-Australasian Journal of Animal Sciences
Volume20
Issue number1
Publication statusPublished - 2007 Jan 1

Fingerprint

insulin-like growth factor II
Insulin-Like Growth Factor II
somatomedins
insulin-like growth factor I
parity (reproduction)
Parity
Insulin-Like Growth Factor I
Lactation
Milk
lactation
milk
parturition
cow colostrum
cows
Parturition
lactation stage
Colostrum
somatic cell count
proximate composition
radioimmunoassays

Keywords

  • Insulin growth factor-I and -II
  • Lactation period
  • Parity
  • Radioimmunoassay
  • Somatic cell

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Changes in the levels of insulin-like growth factors (IGF-I and IGF-II) in bovine milk according to the lactation period and parity. / Kang, S. H.; Kim, J. U.; Kim, Y.; Han, K. S.; Lee, W. J.; Imm, J. Y.; Oh, S.; Park, D. J.; Moon, Y. I.; Kim, Sae Hun.

In: Asian-Australasian Journal of Animal Sciences, Vol. 20, No. 1, 01.01.2007, p. 119-123.

Research output: Contribution to journalArticle

Kang, S. H. ; Kim, J. U. ; Kim, Y. ; Han, K. S. ; Lee, W. J. ; Imm, J. Y. ; Oh, S. ; Park, D. J. ; Moon, Y. I. ; Kim, Sae Hun. / Changes in the levels of insulin-like growth factors (IGF-I and IGF-II) in bovine milk according to the lactation period and parity. In: Asian-Australasian Journal of Animal Sciences. 2007 ; Vol. 20, No. 1. pp. 119-123.
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