Changing patterns of multiple sclerosis in Korea

Toward a more baseline MRI lesions and intrathecal humoral immune responses

Hyun June Shin, Jae Won Hyun, Su Hyun Kim, Min Su Park, Eun Hee Sohn, Seol Hee Baek, Byung Jo Kim, Kyomin Choi, Jeeyoung Oh, Joong Yang Cho, Ohyun Kwon, Woojun Kim, Jee Eun Kim, Ju Hong Min, Byoung Joon Kim, Sun Young Oh, Jong Seok Bae, Kee Hong Park, Jung Hwan Oh, Sung Yeon Sohn & 4 others Myoung Jin Jang, Jung Joon Sung, Ho Jin Kim, Sung Min Kim

Research output: Contribution to journalArticle

Abstract

Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalMultiple Sclerosis and Related Disorders
Volume35
DOIs
Publication statusPublished - 2019 Oct 1

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Korea
Humoral Immunity
Multiple Sclerosis
Magnetic Resonance Imaging
Parturition
Cerebrospinal Fluid
Oligoclonal Bands
Vitamin D Deficiency
Pediatric Obesity
Referral and Consultation
Demography

Keywords

  • Asian
  • Epidemiology
  • MRI
  • Multiple sclerosis
  • Oligoclonal band

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Changing patterns of multiple sclerosis in Korea : Toward a more baseline MRI lesions and intrathecal humoral immune responses. / Shin, Hyun June; Hyun, Jae Won; Kim, Su Hyun; Park, Min Su; Sohn, Eun Hee; Baek, Seol Hee; Kim, Byung Jo; Choi, Kyomin; Oh, Jeeyoung; Cho, Joong Yang; Kwon, Ohyun; Kim, Woojun; Kim, Jee Eun; Min, Ju Hong; Kim, Byoung Joon; Oh, Sun Young; Bae, Jong Seok; Park, Kee Hong; Oh, Jung Hwan; Sohn, Sung Yeon; Jang, Myoung Jin; Sung, Jung Joon; Kim, Ho Jin; Kim, Sung Min.

In: Multiple Sclerosis and Related Disorders, Vol. 35, 01.10.2019, p. 209-214.

Research output: Contribution to journalArticle

Shin, HJ, Hyun, JW, Kim, SH, Park, MS, Sohn, EH, Baek, SH, Kim, BJ, Choi, K, Oh, J, Cho, JY, Kwon, O, Kim, W, Kim, JE, Min, JH, Kim, BJ, Oh, SY, Bae, JS, Park, KH, Oh, JH, Sohn, SY, Jang, MJ, Sung, JJ, Kim, HJ & Kim, SM 2019, 'Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses', Multiple Sclerosis and Related Disorders, vol. 35, pp. 209-214. https://doi.org/10.1016/j.msard.2019.08.004
Shin, Hyun June ; Hyun, Jae Won ; Kim, Su Hyun ; Park, Min Su ; Sohn, Eun Hee ; Baek, Seol Hee ; Kim, Byung Jo ; Choi, Kyomin ; Oh, Jeeyoung ; Cho, Joong Yang ; Kwon, Ohyun ; Kim, Woojun ; Kim, Jee Eun ; Min, Ju Hong ; Kim, Byoung Joon ; Oh, Sun Young ; Bae, Jong Seok ; Park, Kee Hong ; Oh, Jung Hwan ; Sohn, Sung Yeon ; Jang, Myoung Jin ; Sung, Jung Joon ; Kim, Ho Jin ; Kim, Sung Min. / Changing patterns of multiple sclerosis in Korea : Toward a more baseline MRI lesions and intrathecal humoral immune responses. In: Multiple Sclerosis and Related Disorders. 2019 ; Vol. 35. pp. 209-214.
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title = "Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses",
abstract = "Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.",
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T1 - Changing patterns of multiple sclerosis in Korea

T2 - Toward a more baseline MRI lesions and intrathecal humoral immune responses

AU - Shin, Hyun June

AU - Hyun, Jae Won

AU - Kim, Su Hyun

AU - Park, Min Su

AU - Sohn, Eun Hee

AU - Baek, Seol Hee

AU - Kim, Byung Jo

AU - Choi, Kyomin

AU - Oh, Jeeyoung

AU - Cho, Joong Yang

AU - Kwon, Ohyun

AU - Kim, Woojun

AU - Kim, Jee Eun

AU - Min, Ju Hong

AU - Kim, Byoung Joon

AU - Oh, Sun Young

AU - Bae, Jong Seok

AU - Park, Kee Hong

AU - Oh, Jung Hwan

AU - Sohn, Sung Yeon

AU - Jang, Myoung Jin

AU - Sung, Jung Joon

AU - Kim, Ho Jin

AU - Kim, Sung Min

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.

AB - Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.

KW - Asian

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