Chapter 7: Identification of MicroRNAs as Targets for Treatment of Ischemic Stroke

Creed M. Stary, Josh D. Bell, Jang-Eun Cho, Rona G. Giffard

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Ischemic stroke remains a leading cause of death and disability with few treatment options. MicroRNAs (miRs) are short, non-coding RNAs that regulate gene expression. They have important potential applications as biomarkers for stroke severity and outcome, as well as presenting unique possibilities for interventions to minimize injury and improve recovery and outcome following stroke. MiRs function by binding messenger RNAs (mRNA) and silencing translation of target genes. Endogenous miR expression levels change in response to stress, and they can be altered by application of exogenous nucleotides - miR mimics - to increase or inhibitors to decrease levels of specific miRs. By virtue of their relatively short binding sequences, a single miR can simultaneously modulate numerous related gene targets. As miR expression can be cell-type specific, miRs can also be used to target specific brain cell types, such as microglia and astrocytes, which helps determine neuronal cell fate following stress. MiR-based therapeutics may therefore provide a novel approach to the development of effective therapeutics for ischemic stroke.

Original languageEnglish
Title of host publicationDrug Discovery for Leishmaniasis
PublisherRoyal Society of Chemistry
Pages105-127
Number of pages23
Volume2018-January
Edition62
DOIs
Publication statusPublished - 2018 Jan 1

Publication series

NameRSC Drug Discovery Series
Number62
Volume2018-January
ISSN (Print)2041-3203
ISSN (Electronic)2041-3211

ASJC Scopus subject areas

  • Drug Discovery

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  • Cite this

    Stary, C. M., Bell, J. D., Cho, J-E., & Giffard, R. G. (2018). Chapter 7: Identification of MicroRNAs as Targets for Treatment of Ischemic Stroke. In Drug Discovery for Leishmaniasis (62 ed., Vol. 2018-January, pp. 105-127). (RSC Drug Discovery Series; Vol. 2018-January, No. 62). Royal Society of Chemistry. https://doi.org/10.1039/9781788012539-00105