Characteristics and clinical correlates of restless legs syndrome in schizophrenia

Seung Gul Kang, Heon-Jeong Lee, Sung Won Jung, Sung Nam Cho, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective: The cause of restless legs syndrome (RLS) has not yet been ascertained, but one of the most promising theories involves dopaminergic deficiency. In accordance with this theory, we assumed that the prevalence of RLS would be higher among schizophrenics treated with antipsychotics than in the normal population. The purpose of this study was to establish the prevalence, characteristics, and clinical correlates of RLS in schizophrenic patients undergoing treatment with antipsychotics. Methods: A total of 182 hospitalized schizophrenic patients and 108 age- and sex-matched normal controls were enrolled. The presence of RLS and its severity were assessed using the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria and the IRLSSG rating scale, respectively. The Athens Insomnia Scale (AIS), Brief Psychiatric Rating Scale (BPRS), and Barnes Akathisia Rating Scale (BARS) were used to evaluate insomnia, global psychiatric symptoms, and akathisia, respectively, in schizophrenic patients. Results: Of the 182 schizophrenic patients, 39 (21.4%) were found to have RLS and 87 (47.8%) met at least one of the RLS diagnostic criteria. The prevalence of RLS was significantly higher in the schizophrenia group than in the control group (p = 0.009), as were the RLS scores (p < 0.001). The BPRS (p = 0.001) and the AIS (p < 0.001) scores were higher in the RLS group than in the group with no RLS symptoms. Conclusion: We conclude that it is important to consider the diagnosis of RLS when schizophrenic patients complain of insomnia, and that RLS symptoms could be associated with more severe psychiatric symptoms and insomnia.

Original languageEnglish
Pages (from-to)1078-1083
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume31
Issue number5
DOIs
Publication statusPublished - 2007 Jun 30

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Restless Legs Syndrome
Schizophrenia
Sleep Initiation and Maintenance Disorders
Brief Psychiatric Rating Scale
Psychomotor Agitation
Antipsychotic Agents
Psychiatry

Keywords

  • Insomnia
  • Psychiatric symptom
  • Restless legs syndrome
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Characteristics and clinical correlates of restless legs syndrome in schizophrenia. / Kang, Seung Gul; Lee, Heon-Jeong; Jung, Sung Won; Cho, Sung Nam; Han, Changsu; Kim, Yong Ku; Kim, Seung Hyun; Lee, Min-Soo; Joe, Sook Haeng; Jung, In Kwa; Kim, Leen.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 31, No. 5, 30.06.2007, p. 1078-1083.

Research output: Contribution to journalArticle

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abstract = "Objective: The cause of restless legs syndrome (RLS) has not yet been ascertained, but one of the most promising theories involves dopaminergic deficiency. In accordance with this theory, we assumed that the prevalence of RLS would be higher among schizophrenics treated with antipsychotics than in the normal population. The purpose of this study was to establish the prevalence, characteristics, and clinical correlates of RLS in schizophrenic patients undergoing treatment with antipsychotics. Methods: A total of 182 hospitalized schizophrenic patients and 108 age- and sex-matched normal controls were enrolled. The presence of RLS and its severity were assessed using the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria and the IRLSSG rating scale, respectively. The Athens Insomnia Scale (AIS), Brief Psychiatric Rating Scale (BPRS), and Barnes Akathisia Rating Scale (BARS) were used to evaluate insomnia, global psychiatric symptoms, and akathisia, respectively, in schizophrenic patients. Results: Of the 182 schizophrenic patients, 39 (21.4{\%}) were found to have RLS and 87 (47.8{\%}) met at least one of the RLS diagnostic criteria. The prevalence of RLS was significantly higher in the schizophrenia group than in the control group (p = 0.009), as were the RLS scores (p < 0.001). The BPRS (p = 0.001) and the AIS (p < 0.001) scores were higher in the RLS group than in the group with no RLS symptoms. Conclusion: We conclude that it is important to consider the diagnosis of RLS when schizophrenic patients complain of insomnia, and that RLS symptoms could be associated with more severe psychiatric symptoms and insomnia.",
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