Characteristics and outcomes of second malignant neoplasms after childhood cancer treatment

Multi-center retrospective survey

Kyung Nam Koh, Keon Hee Yoo, Ho Joon Im, Ki Woong Sung, Hong Hoe Koo, Hyo Sun Kim, Jung Woo Han, Jong Hyung Yoon, Hyeon Jin Park, Byung Kiu Park, Hee Jo Baek, Hoon Kook, Jun Ah Lee, Jae Min Lee, Kwang Chul Lee, Soon Ki Kim, Meerim Park, Young Ho Lee, Chuhl Joo Lyu, Jong Jin Seo

Research output: Contribution to journalArticle

Abstract

This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5-18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33%) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45% with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18%, 33%, and 32%, respectively, whereas those with second osteosarcoma showed comparable outcomes (64%) to patients with primary counterpart and those with second thyroid carcinoma had a 100% OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.

Original languageEnglish
Pages (from-to)1254-1261
Number of pages8
JournalJournal of Korean Medical Science
Volume31
Issue number8
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Second Primary Neoplasms
Central Nervous System Neoplasms
Neoplasms
Survival Rate
Myelodysplastic Syndromes
Osteosarcoma
Thyroid Neoplasms
Acute Myeloid Leukemia
Therapeutics
Korea
Surveys and Questionnaires
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Non-Hodgkin's Lymphoma
Survivors
Retrospective Studies
Radiation
Survival

Keywords

  • Cancer
  • Childhood
  • Second neoplasm
  • Survivors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Characteristics and outcomes of second malignant neoplasms after childhood cancer treatment : Multi-center retrospective survey. / Koh, Kyung Nam; Yoo, Keon Hee; Im, Ho Joon; Sung, Ki Woong; Koo, Hong Hoe; Kim, Hyo Sun; Han, Jung Woo; Yoon, Jong Hyung; Park, Hyeon Jin; Park, Byung Kiu; Baek, Hee Jo; Kook, Hoon; Lee, Jun Ah; Lee, Jae Min; Lee, Kwang Chul; Kim, Soon Ki; Park, Meerim; Lee, Young Ho; Lyu, Chuhl Joo; Seo, Jong Jin.

In: Journal of Korean Medical Science, Vol. 31, No. 8, 01.01.2016, p. 1254-1261.

Research output: Contribution to journalArticle

Koh, KN, Yoo, KH, Im, HJ, Sung, KW, Koo, HH, Kim, HS, Han, JW, Yoon, JH, Park, HJ, Park, BK, Baek, HJ, Kook, H, Lee, JA, Lee, JM, Lee, KC, Kim, SK, Park, M, Lee, YH, Lyu, CJ & Seo, JJ 2016, 'Characteristics and outcomes of second malignant neoplasms after childhood cancer treatment: Multi-center retrospective survey', Journal of Korean Medical Science, vol. 31, no. 8, pp. 1254-1261. https://doi.org/10.3346/ jkms.2016.31.8.1254
Koh, Kyung Nam ; Yoo, Keon Hee ; Im, Ho Joon ; Sung, Ki Woong ; Koo, Hong Hoe ; Kim, Hyo Sun ; Han, Jung Woo ; Yoon, Jong Hyung ; Park, Hyeon Jin ; Park, Byung Kiu ; Baek, Hee Jo ; Kook, Hoon ; Lee, Jun Ah ; Lee, Jae Min ; Lee, Kwang Chul ; Kim, Soon Ki ; Park, Meerim ; Lee, Young Ho ; Lyu, Chuhl Joo ; Seo, Jong Jin. / Characteristics and outcomes of second malignant neoplasms after childhood cancer treatment : Multi-center retrospective survey. In: Journal of Korean Medical Science. 2016 ; Vol. 31, No. 8. pp. 1254-1261.
@article{e35e169044a944eb9c551299b95875f5,
title = "Characteristics and outcomes of second malignant neoplasms after childhood cancer treatment: Multi-center retrospective survey",
abstract = "This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5-18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33{\%}) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45{\%} with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18{\%}, 33{\%}, and 32{\%}, respectively, whereas those with second osteosarcoma showed comparable outcomes (64{\%}) to patients with primary counterpart and those with second thyroid carcinoma had a 100{\%} OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.",
keywords = "Cancer, Childhood, Second neoplasm, Survivors",
author = "Koh, {Kyung Nam} and Yoo, {Keon Hee} and Im, {Ho Joon} and Sung, {Ki Woong} and Koo, {Hong Hoe} and Kim, {Hyo Sun} and Han, {Jung Woo} and Yoon, {Jong Hyung} and Park, {Hyeon Jin} and Park, {Byung Kiu} and Baek, {Hee Jo} and Hoon Kook and Lee, {Jun Ah} and Lee, {Jae Min} and Lee, {Kwang Chul} and Kim, {Soon Ki} and Meerim Park and Lee, {Young Ho} and Lyu, {Chuhl Joo} and Seo, {Jong Jin}",
year = "2016",
month = "1",
day = "1",
doi = "10.3346/ jkms.2016.31.8.1254",
language = "English",
volume = "31",
pages = "1254--1261",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "8",

}

TY - JOUR

T1 - Characteristics and outcomes of second malignant neoplasms after childhood cancer treatment

T2 - Multi-center retrospective survey

AU - Koh, Kyung Nam

AU - Yoo, Keon Hee

AU - Im, Ho Joon

AU - Sung, Ki Woong

AU - Koo, Hong Hoe

AU - Kim, Hyo Sun

AU - Han, Jung Woo

AU - Yoon, Jong Hyung

AU - Park, Hyeon Jin

AU - Park, Byung Kiu

AU - Baek, Hee Jo

AU - Kook, Hoon

AU - Lee, Jun Ah

AU - Lee, Jae Min

AU - Lee, Kwang Chul

AU - Kim, Soon Ki

AU - Park, Meerim

AU - Lee, Young Ho

AU - Lyu, Chuhl Joo

AU - Seo, Jong Jin

PY - 2016/1/1

Y1 - 2016/1/1

N2 - This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5-18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33%) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45% with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18%, 33%, and 32%, respectively, whereas those with second osteosarcoma showed comparable outcomes (64%) to patients with primary counterpart and those with second thyroid carcinoma had a 100% OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.

AB - This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5-18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33%) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45% with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18%, 33%, and 32%, respectively, whereas those with second osteosarcoma showed comparable outcomes (64%) to patients with primary counterpart and those with second thyroid carcinoma had a 100% OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.

KW - Cancer

KW - Childhood

KW - Second neoplasm

KW - Survivors

UR - http://www.scopus.com/inward/record.url?scp=84978858659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978858659&partnerID=8YFLogxK

U2 - 10.3346/ jkms.2016.31.8.1254

DO - 10.3346/ jkms.2016.31.8.1254

M3 - Article

VL - 31

SP - 1254

EP - 1261

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 8

ER -