Characteristics and prognostic value of papillary histologic subtype in nonmetastatic renal cell carcinoma in Korea: A multicenter study

Won Ki Lee, Sang Eun Lee, Sung Kyu Hong, Chang Wook Jeong, Yong Hyun Park, Seok Ho Kang, Yong June Kim, Sung Hoo Hong, Won Suk Choi, Seok Soo Byun

Research output: Contribution to journalArticle

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Abstract

Purpose: To analyze the characteristics of nonmetastatic papillary renal cell carcinomas (RCC) and the prognostic value of RCC histologic subtyping, based on a large multicenter experience in Korea. Materials and Methods: A total of 2,905 patients with nonmetastatic RCC (TxN0M0) at the time of surgery were retrospectively enrolled from five institutions between 1999 and 2011 in Korea. Among these, patients with clear cell subtype (n = 2,488, 85.6%) and papillary subtype (n = 192, 6.6%) were included in our study. Results: Patients with papillary subtype did not differ significantly from those with clear cell subtype on the following parameters: age (P = .694), gender (P = .511), body mass index (P = .136), patient performance status (P = .419), symptoms at presentation (P = .419), tumor size (P = .778) and pathologic stage (P = .367). However, high Fuhrman's grades were more common in papillary subtypes compared with clear cell subtypes (P = .001). The 5-year recurrence-free survival rates in patients with clear cell subtype and papillary subtype were 84.9% and 86.7%, respectively (P = .167). The 5-year cancer-specific survival rates in patients with clear cell subtype and papillary subtype were 92.0% and 93.1%, respectively (P = .931). Histologic subtype was not an independent prognostic factor of recurrence-free and cancer-specific survival (P = .107 and P = .998, respectively). Conclusion: Our study suggests that the characteristics and prognosis of papillary subtype might be comparable to those of clear cell subtype in non-metastatic RCC, especially in Asia.

Original languageEnglish
Pages (from-to)1884-1890
Number of pages7
JournalUrology Journal
Volume11
Issue number5
Publication statusPublished - 2013 Jan 1

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Korea
Renal Cell Carcinoma
Multicenter Studies
Survival Rate
Recurrence
Neoplasms
Body Mass Index
Survival

Keywords

  • Carcinoma
  • Follow-up studies
  • Kidney neoplasms
  • Papillary
  • Pathology
  • Prognosis
  • Renal cell
  • Retrospective studies

ASJC Scopus subject areas

  • Urology

Cite this

Lee, W. K., Lee, S. E., Hong, S. K., Jeong, C. W., Park, Y. H., Kang, S. H., ... Byun, S. S. (2013). Characteristics and prognostic value of papillary histologic subtype in nonmetastatic renal cell carcinoma in Korea: A multicenter study. Urology Journal, 11(5), 1884-1890.

Characteristics and prognostic value of papillary histologic subtype in nonmetastatic renal cell carcinoma in Korea : A multicenter study. / Lee, Won Ki; Lee, Sang Eun; Hong, Sung Kyu; Jeong, Chang Wook; Park, Yong Hyun; Kang, Seok Ho; Kim, Yong June; Hong, Sung Hoo; Choi, Won Suk; Byun, Seok Soo.

In: Urology Journal, Vol. 11, No. 5, 01.01.2013, p. 1884-1890.

Research output: Contribution to journalArticle

Lee, WK, Lee, SE, Hong, SK, Jeong, CW, Park, YH, Kang, SH, Kim, YJ, Hong, SH, Choi, WS & Byun, SS 2013, 'Characteristics and prognostic value of papillary histologic subtype in nonmetastatic renal cell carcinoma in Korea: A multicenter study', Urology Journal, vol. 11, no. 5, pp. 1884-1890.
Lee, Won Ki ; Lee, Sang Eun ; Hong, Sung Kyu ; Jeong, Chang Wook ; Park, Yong Hyun ; Kang, Seok Ho ; Kim, Yong June ; Hong, Sung Hoo ; Choi, Won Suk ; Byun, Seok Soo. / Characteristics and prognostic value of papillary histologic subtype in nonmetastatic renal cell carcinoma in Korea : A multicenter study. In: Urology Journal. 2013 ; Vol. 11, No. 5. pp. 1884-1890.
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abstract = "Purpose: To analyze the characteristics of nonmetastatic papillary renal cell carcinomas (RCC) and the prognostic value of RCC histologic subtyping, based on a large multicenter experience in Korea. Materials and Methods: A total of 2,905 patients with nonmetastatic RCC (TxN0M0) at the time of surgery were retrospectively enrolled from five institutions between 1999 and 2011 in Korea. Among these, patients with clear cell subtype (n = 2,488, 85.6{\%}) and papillary subtype (n = 192, 6.6{\%}) were included in our study. Results: Patients with papillary subtype did not differ significantly from those with clear cell subtype on the following parameters: age (P = .694), gender (P = .511), body mass index (P = .136), patient performance status (P = .419), symptoms at presentation (P = .419), tumor size (P = .778) and pathologic stage (P = .367). However, high Fuhrman's grades were more common in papillary subtypes compared with clear cell subtypes (P = .001). The 5-year recurrence-free survival rates in patients with clear cell subtype and papillary subtype were 84.9{\%} and 86.7{\%}, respectively (P = .167). The 5-year cancer-specific survival rates in patients with clear cell subtype and papillary subtype were 92.0{\%} and 93.1{\%}, respectively (P = .931). Histologic subtype was not an independent prognostic factor of recurrence-free and cancer-specific survival (P = .107 and P = .998, respectively). Conclusion: Our study suggests that the characteristics and prognosis of papillary subtype might be comparable to those of clear cell subtype in non-metastatic RCC, especially in Asia.",
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T1 - Characteristics and prognostic value of papillary histologic subtype in nonmetastatic renal cell carcinoma in Korea

T2 - A multicenter study

AU - Lee, Won Ki

AU - Lee, Sang Eun

AU - Hong, Sung Kyu

AU - Jeong, Chang Wook

AU - Park, Yong Hyun

AU - Kang, Seok Ho

AU - Kim, Yong June

AU - Hong, Sung Hoo

AU - Choi, Won Suk

AU - Byun, Seok Soo

PY - 2013/1/1

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N2 - Purpose: To analyze the characteristics of nonmetastatic papillary renal cell carcinomas (RCC) and the prognostic value of RCC histologic subtyping, based on a large multicenter experience in Korea. Materials and Methods: A total of 2,905 patients with nonmetastatic RCC (TxN0M0) at the time of surgery were retrospectively enrolled from five institutions between 1999 and 2011 in Korea. Among these, patients with clear cell subtype (n = 2,488, 85.6%) and papillary subtype (n = 192, 6.6%) were included in our study. Results: Patients with papillary subtype did not differ significantly from those with clear cell subtype on the following parameters: age (P = .694), gender (P = .511), body mass index (P = .136), patient performance status (P = .419), symptoms at presentation (P = .419), tumor size (P = .778) and pathologic stage (P = .367). However, high Fuhrman's grades were more common in papillary subtypes compared with clear cell subtypes (P = .001). The 5-year recurrence-free survival rates in patients with clear cell subtype and papillary subtype were 84.9% and 86.7%, respectively (P = .167). The 5-year cancer-specific survival rates in patients with clear cell subtype and papillary subtype were 92.0% and 93.1%, respectively (P = .931). Histologic subtype was not an independent prognostic factor of recurrence-free and cancer-specific survival (P = .107 and P = .998, respectively). Conclusion: Our study suggests that the characteristics and prognosis of papillary subtype might be comparable to those of clear cell subtype in non-metastatic RCC, especially in Asia.

AB - Purpose: To analyze the characteristics of nonmetastatic papillary renal cell carcinomas (RCC) and the prognostic value of RCC histologic subtyping, based on a large multicenter experience in Korea. Materials and Methods: A total of 2,905 patients with nonmetastatic RCC (TxN0M0) at the time of surgery were retrospectively enrolled from five institutions between 1999 and 2011 in Korea. Among these, patients with clear cell subtype (n = 2,488, 85.6%) and papillary subtype (n = 192, 6.6%) were included in our study. Results: Patients with papillary subtype did not differ significantly from those with clear cell subtype on the following parameters: age (P = .694), gender (P = .511), body mass index (P = .136), patient performance status (P = .419), symptoms at presentation (P = .419), tumor size (P = .778) and pathologic stage (P = .367). However, high Fuhrman's grades were more common in papillary subtypes compared with clear cell subtypes (P = .001). The 5-year recurrence-free survival rates in patients with clear cell subtype and papillary subtype were 84.9% and 86.7%, respectively (P = .167). The 5-year cancer-specific survival rates in patients with clear cell subtype and papillary subtype were 92.0% and 93.1%, respectively (P = .931). Histologic subtype was not an independent prognostic factor of recurrence-free and cancer-specific survival (P = .107 and P = .998, respectively). Conclusion: Our study suggests that the characteristics and prognosis of papillary subtype might be comparable to those of clear cell subtype in non-metastatic RCC, especially in Asia.

KW - Carcinoma

KW - Follow-up studies

KW - Kidney neoplasms

KW - Papillary

KW - Pathology

KW - Prognosis

KW - Renal cell

KW - Retrospective studies

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