Characteristics of complex fractionated atrial electrogram in the electroanatomically remodeled left atrium of patients with atrial fibrillation

Jae Hyung Park, Sang Weon Park, Jong Youn Kim, Sook Kyoung Kim, Boyoung Jeoung, Moon Hyung Lee, Chun Hwang, Young Hoon Kim, Sung Soon Kim, Hui Nam Pak

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Complex fractionated atrial electrogram (CFAE) guided ablation is effective in some patients with persistent atrial fbrillation (PeAF), but the pattern of CFAE may be different in the remodeled left atrium (LA).&Methods and Results: In 100 AF patients (83 males, 55.0±10.6 years old) with AF (51 paroxysmal AF (PAF), 49 PeAF) who underwent catheter ablation, CFAE cycle length (CL) and distribution (NavX 3D map) were compared according to the LA volume (3D-CT) and endocardial voltage (during high right atrial pacing 500-ms (Volpace) and AF (Volaf; NavX). The mean CFAE-CL was longer (P=0.003) and the % area CFAE was smaller (P=0.006) in patients with LA>125ml than those with <125ml. The mean CFAE-CL was longer in patients with Volpace <1.7mV than those with >1.7mV (P=0.002) and in Volaf <0.7mVthan >0.7mV (P<0.001). The % area CFAE was smaller in patients with Volpace <1.7mV than those with >1.7mV (P=0.006). The incidence of septal CFAE was consistently high, regardless of the degree of LA remodeling.&Conclusions: In the AF patients with an electroanatomically remodeled LA, the % area of CFAE was smaller and mean CFAE-CL was longer than in those with a less remodeled LA. However, the majority of CFAE are consistently positioned on the septum in the remodeled LA.

Original languageEnglish
Pages (from-to)1557-1563
Number of pages7
JournalCirculation Journal
Volume74
Issue number8
DOIs
Publication statusPublished - 2010 Aug 4

Fingerprint

Cardiac Electrophysiologic Techniques
Heart Atria
Atrial Fibrillation
Atrial Remodeling
Cone-Beam Computed Tomography
Catheter Ablation

Keywords

  • Atrial fbrillation
  • Computed tomography
  • Left atrium
  • Morphological remodeling
  • Voltage mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Characteristics of complex fractionated atrial electrogram in the electroanatomically remodeled left atrium of patients with atrial fibrillation. / Park, Jae Hyung; Park, Sang Weon; Kim, Jong Youn; Kim, Sook Kyoung; Jeoung, Boyoung; Lee, Moon Hyung; Hwang, Chun; Kim, Young Hoon; Kim, Sung Soon; Pak, Hui Nam.

In: Circulation Journal, Vol. 74, No. 8, 04.08.2010, p. 1557-1563.

Research output: Contribution to journalArticle

Park, Jae Hyung ; Park, Sang Weon ; Kim, Jong Youn ; Kim, Sook Kyoung ; Jeoung, Boyoung ; Lee, Moon Hyung ; Hwang, Chun ; Kim, Young Hoon ; Kim, Sung Soon ; Pak, Hui Nam. / Characteristics of complex fractionated atrial electrogram in the electroanatomically remodeled left atrium of patients with atrial fibrillation. In: Circulation Journal. 2010 ; Vol. 74, No. 8. pp. 1557-1563.
@article{2b2b0438242b44e1afd2510e40371975,
title = "Characteristics of complex fractionated atrial electrogram in the electroanatomically remodeled left atrium of patients with atrial fibrillation",
abstract = "Background: Complex fractionated atrial electrogram (CFAE) guided ablation is effective in some patients with persistent atrial fbrillation (PeAF), but the pattern of CFAE may be different in the remodeled left atrium (LA).&Methods and Results: In 100 AF patients (83 males, 55.0±10.6 years old) with AF (51 paroxysmal AF (PAF), 49 PeAF) who underwent catheter ablation, CFAE cycle length (CL) and distribution (NavX 3D map) were compared according to the LA volume (3D-CT) and endocardial voltage (during high right atrial pacing 500-ms (Volpace) and AF (Volaf; NavX). The mean CFAE-CL was longer (P=0.003) and the {\%} area CFAE was smaller (P=0.006) in patients with LA>125ml than those with <125ml. The mean CFAE-CL was longer in patients with Volpace <1.7mV than those with >1.7mV (P=0.002) and in Volaf <0.7mVthan >0.7mV (P<0.001). The {\%} area CFAE was smaller in patients with Volpace <1.7mV than those with >1.7mV (P=0.006). The incidence of septal CFAE was consistently high, regardless of the degree of LA remodeling.&Conclusions: In the AF patients with an electroanatomically remodeled LA, the {\%} area of CFAE was smaller and mean CFAE-CL was longer than in those with a less remodeled LA. However, the majority of CFAE are consistently positioned on the septum in the remodeled LA.",
keywords = "Atrial fbrillation, Computed tomography, Left atrium, Morphological remodeling, Voltage mapping",
author = "Park, {Jae Hyung} and Park, {Sang Weon} and Kim, {Jong Youn} and Kim, {Sook Kyoung} and Boyoung Jeoung and Lee, {Moon Hyung} and Chun Hwang and Kim, {Young Hoon} and Kim, {Sung Soon} and Pak, {Hui Nam}",
year = "2010",
month = "8",
day = "4",
doi = "10.1253/circj.CJ-10-0048",
language = "English",
volume = "74",
pages = "1557--1563",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "8",

}

TY - JOUR

T1 - Characteristics of complex fractionated atrial electrogram in the electroanatomically remodeled left atrium of patients with atrial fibrillation

AU - Park, Jae Hyung

AU - Park, Sang Weon

AU - Kim, Jong Youn

AU - Kim, Sook Kyoung

AU - Jeoung, Boyoung

AU - Lee, Moon Hyung

AU - Hwang, Chun

AU - Kim, Young Hoon

AU - Kim, Sung Soon

AU - Pak, Hui Nam

PY - 2010/8/4

Y1 - 2010/8/4

N2 - Background: Complex fractionated atrial electrogram (CFAE) guided ablation is effective in some patients with persistent atrial fbrillation (PeAF), but the pattern of CFAE may be different in the remodeled left atrium (LA).&Methods and Results: In 100 AF patients (83 males, 55.0±10.6 years old) with AF (51 paroxysmal AF (PAF), 49 PeAF) who underwent catheter ablation, CFAE cycle length (CL) and distribution (NavX 3D map) were compared according to the LA volume (3D-CT) and endocardial voltage (during high right atrial pacing 500-ms (Volpace) and AF (Volaf; NavX). The mean CFAE-CL was longer (P=0.003) and the % area CFAE was smaller (P=0.006) in patients with LA>125ml than those with <125ml. The mean CFAE-CL was longer in patients with Volpace <1.7mV than those with >1.7mV (P=0.002) and in Volaf <0.7mVthan >0.7mV (P<0.001). The % area CFAE was smaller in patients with Volpace <1.7mV than those with >1.7mV (P=0.006). The incidence of septal CFAE was consistently high, regardless of the degree of LA remodeling.&Conclusions: In the AF patients with an electroanatomically remodeled LA, the % area of CFAE was smaller and mean CFAE-CL was longer than in those with a less remodeled LA. However, the majority of CFAE are consistently positioned on the septum in the remodeled LA.

AB - Background: Complex fractionated atrial electrogram (CFAE) guided ablation is effective in some patients with persistent atrial fbrillation (PeAF), but the pattern of CFAE may be different in the remodeled left atrium (LA).&Methods and Results: In 100 AF patients (83 males, 55.0±10.6 years old) with AF (51 paroxysmal AF (PAF), 49 PeAF) who underwent catheter ablation, CFAE cycle length (CL) and distribution (NavX 3D map) were compared according to the LA volume (3D-CT) and endocardial voltage (during high right atrial pacing 500-ms (Volpace) and AF (Volaf; NavX). The mean CFAE-CL was longer (P=0.003) and the % area CFAE was smaller (P=0.006) in patients with LA>125ml than those with <125ml. The mean CFAE-CL was longer in patients with Volpace <1.7mV than those with >1.7mV (P=0.002) and in Volaf <0.7mVthan >0.7mV (P<0.001). The % area CFAE was smaller in patients with Volpace <1.7mV than those with >1.7mV (P=0.006). The incidence of septal CFAE was consistently high, regardless of the degree of LA remodeling.&Conclusions: In the AF patients with an electroanatomically remodeled LA, the % area of CFAE was smaller and mean CFAE-CL was longer than in those with a less remodeled LA. However, the majority of CFAE are consistently positioned on the septum in the remodeled LA.

KW - Atrial fbrillation

KW - Computed tomography

KW - Left atrium

KW - Morphological remodeling

KW - Voltage mapping

UR - http://www.scopus.com/inward/record.url?scp=77955071153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955071153&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-10-0048

DO - 10.1253/circj.CJ-10-0048

M3 - Article

VL - 74

SP - 1557

EP - 1563

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 8

ER -