Characteristics of felodipine-located poly(ε-caprolactone) microspheres

B. K. Kim, S. J. Hwang, J. B. Park, H. J. Park

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Felodipine-loaded poly (ε-caprolactone) (PCL) microspheres were prepared by two methods, the conventional emulsion solvent evapouration method and the quenching method. The aim of this work was to investigate the effects of process parameters such as emulsion type, drug loading, molecular-weight of the polymer, types of emulsion stabilizer and dispersed phase solvents, as well as preparation methods. The results show that, when conventional emulsion solvent evapouration method was used, the o/w-method produced smaller mean size and higher encapsulation efficiency compared with the o/o-method. The encapsulation efficiencies increased with an increase in the molecular weight and a decrease in crystallinity of PCL. The size of microspheres varied with the type of emulsion stabilizer used, smaller microspheres with PVA and narrow size distribution with Pol 237. The water solubility of the dispersed phase solvent was one of the critical factors in controlling the encapsulation efficiency and microsphere mean size. When water-soluble solvents such as acetonitrile and ethyl formate were used, the encapsulation efficiencies decreased due to higher evapouration rate. When quenching methods were used, in contrast to the conventional emulsion solvent evapouration method, very narrowly size-distributed but bigger microspheres were obtained.

Original languageEnglish
Pages (from-to)193-203
Number of pages11
JournalJournal of Microencapsulation
Volume22
Issue number2
DOIs
Publication statusPublished - 2005 Mar

Keywords

  • Conventional emulsion solvent evapouration method
  • Felodipine
  • Microsphere
  • Poly(ε-caprolactone)
  • Quenching method

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

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