Abstract
Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disease characterized by cervical lymphadenopathy. Although it was primarily thought to be a disease of young adults, it has been increasingly recognized in children. To define the characteristics of KFD in children, we reviewed the medical records of patients younger than 18 years of age who were diagnosed with KFD from 2001 to 2012 at Korea University Medical Center, as well as worldwide published reports of KFD. A total of 140 pediatric patients and 733 patients of all ages was analyzed. Compared to the female predominance found in adults (2:1), young boys were more commonly affected than young girls (1.4:1). Cervical lymphadenopathy was the most common clinical finding in children, as it was in adults. Lymphadenopathy was more likely to be tender (69 vs. 44 %, p < 0.001) but less generalized (1 vs. 8 %, p < 0.05) in children compared to adults. Fever (82 vs. 35 %, p < 0.001) and rash (10 vs. 4 %, p < 0.05) were observed in children more commonly than in adults. Leukopenia was observed in 50 and 38 % of children and adults, respectively. Rates of recurrence and association with autoimmune diseases in children were comparable to those of adults. Cervical lymphadenopathy was the most common clinical manifestation of KFD in all ages. While fever and rash were more common in children with KFD compared to adults, generalized lymphadenopathy was rarer.
| Original language | English |
|---|---|
| Pages (from-to) | 111-116 |
| Number of pages | 6 |
| Journal | European Journal of Pediatrics |
| Volume | 173 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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Keywords
- Children
- Fever
- Kikuchi-Fujimoto disease
- Lymphadenopathy
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Characteristics of Kikuchi-Fujimoto disease in children compared with adults. / Kim, Tae Yeun; Ha, Kee Soo; Kim, Yun Kyung; Lee, Jung Hwa; Lee, Kwang Chul; Lee, Joowon.
In: European Journal of Pediatrics, Vol. 173, No. 1, 01.01.2014, p. 111-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characteristics of Kikuchi-Fujimoto disease in children compared with adults
AU - Kim, Tae Yeun
AU - Ha, Kee Soo
AU - Kim, Yun Kyung
AU - Lee, Jung Hwa
AU - Lee, Kwang Chul
AU - Lee, Joowon
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disease characterized by cervical lymphadenopathy. Although it was primarily thought to be a disease of young adults, it has been increasingly recognized in children. To define the characteristics of KFD in children, we reviewed the medical records of patients younger than 18 years of age who were diagnosed with KFD from 2001 to 2012 at Korea University Medical Center, as well as worldwide published reports of KFD. A total of 140 pediatric patients and 733 patients of all ages was analyzed. Compared to the female predominance found in adults (2:1), young boys were more commonly affected than young girls (1.4:1). Cervical lymphadenopathy was the most common clinical finding in children, as it was in adults. Lymphadenopathy was more likely to be tender (69 vs. 44 %, p < 0.001) but less generalized (1 vs. 8 %, p < 0.05) in children compared to adults. Fever (82 vs. 35 %, p < 0.001) and rash (10 vs. 4 %, p < 0.05) were observed in children more commonly than in adults. Leukopenia was observed in 50 and 38 % of children and adults, respectively. Rates of recurrence and association with autoimmune diseases in children were comparable to those of adults. Cervical lymphadenopathy was the most common clinical manifestation of KFD in all ages. While fever and rash were more common in children with KFD compared to adults, generalized lymphadenopathy was rarer.
AB - Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disease characterized by cervical lymphadenopathy. Although it was primarily thought to be a disease of young adults, it has been increasingly recognized in children. To define the characteristics of KFD in children, we reviewed the medical records of patients younger than 18 years of age who were diagnosed with KFD from 2001 to 2012 at Korea University Medical Center, as well as worldwide published reports of KFD. A total of 140 pediatric patients and 733 patients of all ages was analyzed. Compared to the female predominance found in adults (2:1), young boys were more commonly affected than young girls (1.4:1). Cervical lymphadenopathy was the most common clinical finding in children, as it was in adults. Lymphadenopathy was more likely to be tender (69 vs. 44 %, p < 0.001) but less generalized (1 vs. 8 %, p < 0.05) in children compared to adults. Fever (82 vs. 35 %, p < 0.001) and rash (10 vs. 4 %, p < 0.05) were observed in children more commonly than in adults. Leukopenia was observed in 50 and 38 % of children and adults, respectively. Rates of recurrence and association with autoimmune diseases in children were comparable to those of adults. Cervical lymphadenopathy was the most common clinical manifestation of KFD in all ages. While fever and rash were more common in children with KFD compared to adults, generalized lymphadenopathy was rarer.
KW - Children
KW - Fever
KW - Kikuchi-Fujimoto disease
KW - Lymphadenopathy
UR - http://www.scopus.com/inward/record.url?scp=84893649807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893649807&partnerID=8YFLogxK
U2 - 10.1007/s00431-013-2131-3
DO - 10.1007/s00431-013-2131-3
M3 - Article
C2 - 23955486
AN - SCOPUS:84893649807
VL - 173
SP - 111
EP - 116
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 1
ER -