Abstract
Background: Previous studies suggest that there is a strong association between depression and cognitive decline, and that concurrent depressive symptoms in MCI patients could contribute to a difference in neurocognitive characteristics compared to MCI patients without depression. The authors tried to compare neurocognitive functions between MCI patients with and without depression by analyzing the results of neuropsychological tests. Methods: Participants included 153 MCI patients. Based on the diagnosis of major depressive disorder, the participants were divided into two groups: depressed MCI (MCI/D+) versus non-depressed MCI (MCI/D-). The general cognitive and functional statuses of participants were evaluated. And a subset of various neuropsychological tests was presented to participants. Demographic and clinical data were analyzed using Student t-test or χ 2 test. Results: A total of 153 participants were divided into two groups: 94 MCI/D+ patients and 59 MCI/D- patients. Age, sex, and years of education were not significantly different between the two groups. There were no significant differences in general cognitive status between MCI/D+ and MCI/D- patients, but MCI/D+ participants showed significantly reduced performance in the six subtests (Contrasting Program, Go-no-go task, Fist-edge-palm task, Constructional Praxis, Memory Recall, TMT-A) compared with MCI/D- patients. Conclusions: There were significantly greater deficits in neurocognitive functions including verbal memory, executive function, attention/processing speed, and visual memory in MCI/D+ participants compared to MCI/D-. Once the biological mechanism is identified, distinct approaches in treatment or prevention will be determined.
| Original language | English |
|---|---|
| Pages (from-to) | 1181-1190 |
| Number of pages | 10 |
| Journal | International Psychogeriatrics |
| Volume | 28 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2016 Jul 1 |
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Keywords
- Alzheimer's disease
- depression
- mild cognitive impairment
- neurocognitive function
- neuropsychology
ASJC Scopus subject areas
- Clinical Psychology
- Gerontology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Characteristics of neurocognitive functions in mild cognitive impairment with depression. / Dong, Hyun Seok; Han, Changsu; Jeon, Sang Won; Yoon, Seoyoung; Jeong, Hyun-Ghang; Huh, Yu Jeong; Pae, Chi Un; Patkar, Ashwin A.; Steffens, David C.
In: International Psychogeriatrics, Vol. 28, No. 7, 01.07.2016, p. 1181-1190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characteristics of neurocognitive functions in mild cognitive impairment with depression
AU - Dong, Hyun Seok
AU - Han, Changsu
AU - Jeon, Sang Won
AU - Yoon, Seoyoung
AU - Jeong, Hyun-Ghang
AU - Huh, Yu Jeong
AU - Pae, Chi Un
AU - Patkar, Ashwin A.
AU - Steffens, David C.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background: Previous studies suggest that there is a strong association between depression and cognitive decline, and that concurrent depressive symptoms in MCI patients could contribute to a difference in neurocognitive characteristics compared to MCI patients without depression. The authors tried to compare neurocognitive functions between MCI patients with and without depression by analyzing the results of neuropsychological tests. Methods: Participants included 153 MCI patients. Based on the diagnosis of major depressive disorder, the participants were divided into two groups: depressed MCI (MCI/D+) versus non-depressed MCI (MCI/D-). The general cognitive and functional statuses of participants were evaluated. And a subset of various neuropsychological tests was presented to participants. Demographic and clinical data were analyzed using Student t-test or χ 2 test. Results: A total of 153 participants were divided into two groups: 94 MCI/D+ patients and 59 MCI/D- patients. Age, sex, and years of education were not significantly different between the two groups. There were no significant differences in general cognitive status between MCI/D+ and MCI/D- patients, but MCI/D+ participants showed significantly reduced performance in the six subtests (Contrasting Program, Go-no-go task, Fist-edge-palm task, Constructional Praxis, Memory Recall, TMT-A) compared with MCI/D- patients. Conclusions: There were significantly greater deficits in neurocognitive functions including verbal memory, executive function, attention/processing speed, and visual memory in MCI/D+ participants compared to MCI/D-. Once the biological mechanism is identified, distinct approaches in treatment or prevention will be determined.
AB - Background: Previous studies suggest that there is a strong association between depression and cognitive decline, and that concurrent depressive symptoms in MCI patients could contribute to a difference in neurocognitive characteristics compared to MCI patients without depression. The authors tried to compare neurocognitive functions between MCI patients with and without depression by analyzing the results of neuropsychological tests. Methods: Participants included 153 MCI patients. Based on the diagnosis of major depressive disorder, the participants were divided into two groups: depressed MCI (MCI/D+) versus non-depressed MCI (MCI/D-). The general cognitive and functional statuses of participants were evaluated. And a subset of various neuropsychological tests was presented to participants. Demographic and clinical data were analyzed using Student t-test or χ 2 test. Results: A total of 153 participants were divided into two groups: 94 MCI/D+ patients and 59 MCI/D- patients. Age, sex, and years of education were not significantly different between the two groups. There were no significant differences in general cognitive status between MCI/D+ and MCI/D- patients, but MCI/D+ participants showed significantly reduced performance in the six subtests (Contrasting Program, Go-no-go task, Fist-edge-palm task, Constructional Praxis, Memory Recall, TMT-A) compared with MCI/D- patients. Conclusions: There were significantly greater deficits in neurocognitive functions including verbal memory, executive function, attention/processing speed, and visual memory in MCI/D+ participants compared to MCI/D-. Once the biological mechanism is identified, distinct approaches in treatment or prevention will be determined.
KW - Alzheimer's disease
KW - depression
KW - mild cognitive impairment
KW - neurocognitive function
KW - neuropsychology
UR - http://www.scopus.com/inward/record.url?scp=84960105550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960105550&partnerID=8YFLogxK
U2 - 10.1017/S1041610216000314
DO - 10.1017/S1041610216000314
M3 - Article
C2 - 26960534
AN - SCOPUS:84960105550
VL - 28
SP - 1181
EP - 1190
JO - International Psychogeriatrics
JF - International Psychogeriatrics
SN - 1041-6102
IS - 7
ER -