Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction: A retrospective analysis of comparing haematological parameters and C reactive protein

Jong Han Lee, Kyum Yil Kwon, Soo-Young Yoon, Hyon Suk Kim, Chae Seung Lim

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Abstract

Objective: Elevation of C reactive protein (CRP) is one of the major acute-phase responses following ischaemic or haemorrhagic stroke. This study aims to investigate the associations between platelet indices, neutrophil-to-lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) compared with CRP in patients with cerebral infarction. Setting: The clinical data of patients with cerebral infarction were analysed retrospectively.

Participants: We analysed, unduplicated, 516 patients with cerebral infarction (mean age 66.2 ±12.7, male/female=291/225). Outcome measures: Mean platelet volume (MPV), MPV to platelet count, NLR and ESR were compared with CRP in patients with cerebral infarction in a single institute through Spearman correlation test.

Results: There were significant correlations between CRP and MPV (ρ=0.088, p=0.045), NLR (ρ=0.4, p<0.001) and ESR (ρ=0.468, p<0.001) in patients with cerebral infarction. In the male group, NLR (ρ=0.398, p<0.001) and ESR (ρ=0.502, p<0.001) showed significant correlations with CRP. In the female group, CRP showed significant correlations with MPV (ρ=0.17, p=0.011), NLR (ρ=0.392, p<0.001) and ESR (ρ=0.475, p<0.001).

Conclusions: MPV, NLR and ESR showed significant correlation with CRP in patients with cerebral infarction. MPV and NLR are cost-effective and simple parameters that can be attainable by using an automatic haematology analyser. Further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction.

Original languageEnglish
Article number006275
JournalBMJ Open
Volume4
Issue number11
DOIs
Publication statusPublished - 2014 Jan 1

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Blood Sedimentation
Cerebral Infarction
Mean Platelet Volume
C-Reactive Protein
Neutrophils
Blood Platelets
Lymphocytes
Acute-Phase Reaction
Physiologic Monitoring
Hematology
Platelet Count
Stroke
Outcome Assessment (Health Care)
Prospective Studies
Costs and Cost Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{760a9dee16e84c44879c5d24d3dbf737,
title = "Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction: A retrospective analysis of comparing haematological parameters and C reactive protein",
abstract = "Objective: Elevation of C reactive protein (CRP) is one of the major acute-phase responses following ischaemic or haemorrhagic stroke. This study aims to investigate the associations between platelet indices, neutrophil-to-lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) compared with CRP in patients with cerebral infarction. Setting: The clinical data of patients with cerebral infarction were analysed retrospectively.Participants: We analysed, unduplicated, 516 patients with cerebral infarction (mean age 66.2 ±12.7, male/female=291/225). Outcome measures: Mean platelet volume (MPV), MPV to platelet count, NLR and ESR were compared with CRP in patients with cerebral infarction in a single institute through Spearman correlation test.Results: There were significant correlations between CRP and MPV (ρ=0.088, p=0.045), NLR (ρ=0.4, p<0.001) and ESR (ρ=0.468, p<0.001) in patients with cerebral infarction. In the male group, NLR (ρ=0.398, p<0.001) and ESR (ρ=0.502, p<0.001) showed significant correlations with CRP. In the female group, CRP showed significant correlations with MPV (ρ=0.17, p=0.011), NLR (ρ=0.392, p<0.001) and ESR (ρ=0.475, p<0.001).Conclusions: MPV, NLR and ESR showed significant correlation with CRP in patients with cerebral infarction. MPV and NLR are cost-effective and simple parameters that can be attainable by using an automatic haematology analyser. Further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction.",
author = "Lee, {Jong Han} and Kwon, {Kyum Yil} and Soo-Young Yoon and Kim, {Hyon Suk} and Lim, {Chae Seung}",
year = "2014",
month = "1",
day = "1",
doi = "10.1136/bmjopen-2014-006275",
language = "English",
volume = "4",
journal = "BMJ Open",
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TY - JOUR

T1 - Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction

T2 - A retrospective analysis of comparing haematological parameters and C reactive protein

AU - Lee, Jong Han

AU - Kwon, Kyum Yil

AU - Yoon, Soo-Young

AU - Kim, Hyon Suk

AU - Lim, Chae Seung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: Elevation of C reactive protein (CRP) is one of the major acute-phase responses following ischaemic or haemorrhagic stroke. This study aims to investigate the associations between platelet indices, neutrophil-to-lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) compared with CRP in patients with cerebral infarction. Setting: The clinical data of patients with cerebral infarction were analysed retrospectively.Participants: We analysed, unduplicated, 516 patients with cerebral infarction (mean age 66.2 ±12.7, male/female=291/225). Outcome measures: Mean platelet volume (MPV), MPV to platelet count, NLR and ESR were compared with CRP in patients with cerebral infarction in a single institute through Spearman correlation test.Results: There were significant correlations between CRP and MPV (ρ=0.088, p=0.045), NLR (ρ=0.4, p<0.001) and ESR (ρ=0.468, p<0.001) in patients with cerebral infarction. In the male group, NLR (ρ=0.398, p<0.001) and ESR (ρ=0.502, p<0.001) showed significant correlations with CRP. In the female group, CRP showed significant correlations with MPV (ρ=0.17, p=0.011), NLR (ρ=0.392, p<0.001) and ESR (ρ=0.475, p<0.001).Conclusions: MPV, NLR and ESR showed significant correlation with CRP in patients with cerebral infarction. MPV and NLR are cost-effective and simple parameters that can be attainable by using an automatic haematology analyser. Further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction.

AB - Objective: Elevation of C reactive protein (CRP) is one of the major acute-phase responses following ischaemic or haemorrhagic stroke. This study aims to investigate the associations between platelet indices, neutrophil-to-lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) compared with CRP in patients with cerebral infarction. Setting: The clinical data of patients with cerebral infarction were analysed retrospectively.Participants: We analysed, unduplicated, 516 patients with cerebral infarction (mean age 66.2 ±12.7, male/female=291/225). Outcome measures: Mean platelet volume (MPV), MPV to platelet count, NLR and ESR were compared with CRP in patients with cerebral infarction in a single institute through Spearman correlation test.Results: There were significant correlations between CRP and MPV (ρ=0.088, p=0.045), NLR (ρ=0.4, p<0.001) and ESR (ρ=0.468, p<0.001) in patients with cerebral infarction. In the male group, NLR (ρ=0.398, p<0.001) and ESR (ρ=0.502, p<0.001) showed significant correlations with CRP. In the female group, CRP showed significant correlations with MPV (ρ=0.17, p=0.011), NLR (ρ=0.392, p<0.001) and ESR (ρ=0.475, p<0.001).Conclusions: MPV, NLR and ESR showed significant correlation with CRP in patients with cerebral infarction. MPV and NLR are cost-effective and simple parameters that can be attainable by using an automatic haematology analyser. Further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction.

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U2 - 10.1136/bmjopen-2014-006275

DO - 10.1136/bmjopen-2014-006275

M3 - Article

C2 - 25412865

AN - SCOPUS:84911948456

VL - 4

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 11

M1 - 006275

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