Characterization and improvement of dissolution rate of solid dispersion of celecoxib in PVP K30/eudragit EPO

Dae Yeon Jeon, Ji Eun Jang, Jeong Hwan Lee, Jae Won Yang, Sang Mi Park, Dong-Kwon Lim, Gilson Khang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres®). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

Original languageEnglish
Pages (from-to)434-440
Number of pages7
JournalPolymer (Korea)
Volume38
Issue number4
DOIs
Publication statusPublished - 2014 Jul 1
Externally publishedYes

Keywords

  • Celecoxib
  • Eudragit EPO
  • PVP K30
  • Solid dispersion
  • Spray drying

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

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