Characterization and improvement of dissolution rate of solid dispersion of celecoxib in PVP K30/eudragit EPO

Dae Yeon Jeon; Ji Eun Jang; Jeong Hwan Lee; Jae Won Yang; Sang Mi Park; Dong-Kwon Lim; Gilson Khang

doi:10.7317/pk.2014.38.4.434

Characterization and improvement of dissolution rate of solid dispersion of celecoxib in PVP K30/eudragit EPO

Dae Yeon Jeon, Ji Eun Jang, Jeong Hwan Lee, Jae Won Yang, Sang Mi Park, Dong-Kwon Lim, Gilson Khang

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres^®). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

Original language	English
Pages (from-to)	434-440
Number of pages	7
Journal	Polymer (Korea)
Volume	38
Issue number	4
DOIs	https://doi.org/10.7317/pk.2014.38.4.434
Publication status	Published - 2014 Jul 1
Externally published	Yes

Keywords

Celecoxib
Eudragit EPO
PVP K30
Solid dispersion
Spray drying

ASJC Scopus subject areas

Chemical Engineering(all)
Polymers and Plastics
Materials Chemistry

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Jeon, D. Y., Jang, J. E., Lee, J. H., Yang, J. W., Park, S. M., Lim, D-K., & Khang, G. (2014). Characterization and improvement of dissolution rate of solid dispersion of celecoxib in PVP K30/eudragit EPO. Polymer (Korea), 38(4), 434-440. https://doi.org/10.7317/pk.2014.38.4.434

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title = "Characterization and improvement of dissolution rate of solid dispersion of celecoxib in PVP K30/eudragit EPO",

abstract = "We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres{\textregistered}). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.",

keywords = "Celecoxib, Eudragit EPO, PVP K30, Solid dispersion, Spray drying",

author = "Jeon, {Dae Yeon} and Jang, {Ji Eun} and Lee, {Jeong Hwan} and Yang, {Jae Won} and Park, {Sang Mi} and Dong-Kwon Lim and Gilson Khang",

year = "2014",

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doi = "10.7317/pk.2014.38.4.434",

language = "English",

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AU - Jeon, Dae Yeon

AU - Jang, Ji Eun

AU - Lee, Jeong Hwan

AU - Yang, Jae Won

AU - Park, Sang Mi

AU - Lim, Dong-Kwon

AU - Khang, Gilson

PY - 2014/7/1

Y1 - 2014/7/1

N2 - We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres®). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

AB - We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres®). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

KW - Celecoxib

KW - Eudragit EPO

KW - PVP K30

KW - Solid dispersion

KW - Spray drying

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