Abstract
We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres®). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.
| Original language | English |
|---|---|
| Pages (from-to) | 434-440 |
| Number of pages | 7 |
| Journal | Polymer (Korea) |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 Jul 1 |
| Externally published | Yes |
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Keywords
- Celecoxib
- Eudragit EPO
- PVP K30
- Solid dispersion
- Spray drying
ASJC Scopus subject areas
- Chemical Engineering(all)
- Polymers and Plastics
- Materials Chemistry
Cite this
Characterization and improvement of dissolution rate of solid dispersion of celecoxib in PVP K30/eudragit EPO. / Jeon, Dae Yeon; Jang, Ji Eun; Lee, Jeong Hwan; Yang, Jae Won; Park, Sang Mi; Lim, Dong-Kwon; Khang, Gilson.
In: Polymer (Korea), Vol. 38, No. 4, 01.07.2014, p. 434-440.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization and improvement of dissolution rate of solid dispersion of celecoxib in PVP K30/eudragit EPO
AU - Jeon, Dae Yeon
AU - Jang, Ji Eun
AU - Lee, Jeong Hwan
AU - Yang, Jae Won
AU - Park, Sang Mi
AU - Lim, Dong-Kwon
AU - Khang, Gilson
PY - 2014/7/1
Y1 - 2014/7/1
N2 - We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres®). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.
AB - We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres®). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.
KW - Celecoxib
KW - Eudragit EPO
KW - PVP K30
KW - Solid dispersion
KW - Spray drying
UR - http://www.scopus.com/inward/record.url?scp=84930829260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930829260&partnerID=8YFLogxK
U2 - 10.7317/pk.2014.38.4.434
DO - 10.7317/pk.2014.38.4.434
M3 - Article
AN - SCOPUS:84930829260
VL - 38
SP - 434
EP - 440
JO - Polymer (Korea)
JF - Polymer (Korea)
SN - 0379-153X
IS - 4
ER -